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Details on Person L1-L1 trans-homodimers interact with the fibroblast growth f...
| Class:Id | Summation:437241 |
|---|---|
| _displayName | L1-L1 trans-homodimers interact with the fibroblast growth f... |
| _timestamp | 2010-03-16 17:38:36 |
| created | [InstanceEdit:437236] Garapati, P V, 2009-09-14 |
| modified | [InstanceEdit:437249] Garapati, P V, 2009-09-14 [InstanceEdit:443578] Garapati, P V, 2009-10-12 [InstanceEdit:451256] Garapati, P V, 2009-12-30 [InstanceEdit:549028] Garapati, P V, 2010-03-16 |
| text | L1-L1 trans-homodimers interact with the fibroblast growth factor receptor (FGFR). The CAM homology domain (CHD) in the FGFR, which resides between Ig like domains 1 and 2, interacts with the putative FGFR-CHD binding motif in the Fn3 module 4 of L1. This interaction leads to activation of the tyrosine kinase domain of the FGFR and subsequent activation of PLCgamma. PLCgamma then hydrolyses PIP2 to generate IP3 and DAG which finally leads to an increase in localized Ca+2 influx and activation of Ca+2/Calmodulin kinase II. |
| (summation) | [Reaction:437230] L1-FGFR cis-heterodimerization [Homo sapiens] |
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No pathways have been reviewed or authored by L1-L1 trans-homodimers interact with the fibroblast growth f... (437241)
