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Details on Person UniProt:O75521-2 ECI2
| Class:Id | ReferenceIsoform:436229 |
|---|---|
| _chainChangeLog | transit peptide:1-38 added on Sat February 7 2015;chain:39-394 added on Sat February 7 2015 |
| _displayName | UniProt:O75521-2 ECI2 |
| _timestamp | 2024-11-03 20:14:13 |
| chain | transit peptide:1-38 chain:39-394 |
| checksum | 8AC633D43A320102 |
| comment | FUNCTION Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates.CATALYTIC ACTIVITY a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoACATALYTIC ACTIVITY (3Z)-octenoyl-CoA = (2E)-octenoyl-CoACATALYTIC ACTIVITY a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoACATALYTIC ACTIVITY (2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoACATALYTIC ACTIVITY (3E)-tetradecenoyl-CoA = (2E)-tetradecenoyl-CoACATALYTIC ACTIVITY (3E)-octenoyl-CoA = (2E)-octenoyl-CoACATALYTIC ACTIVITY (3E)-nonenoyl-CoA = (2E)-nonenoyl-CoAPATHWAY Lipid metabolism; fatty acid beta-oxidation.INTERACTION Abundant in heart, skeletal muscle and liver. Expressed in CD34(+) T-cells and CD34(+) bone marrow cells.SIMILARITY In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.CAUTION It is uncertain whether Met-1 or Met-3 is the initiator.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:435871] Kanapin, AA |
| description | recommendedName: fullName evidence="15"Enoyl-CoA delta isomerase 2 ecNumber evidence="8"5.3.3.8 alternativeName: DRS-1 alternativeName: Delta(3),delta(2)-enoyl-CoA isomerase shortName: D3,D2-enoyl-CoA isomerase alternativeName: Diazepam-binding inhibitor-related protein 1 shortName: DBI-related protein 1 alternativeName: Dodecenoyl-CoA isomerase alternativeName: Hepatocellular carcinoma-associated antigen 88 alternativeName: Peroxisomal 3,2-trans-enoyl-CoA isomerase shortName evidence="12"pECI alternativeName: Renal carcinoma antigen NY-REN-1 |
| geneName | ECI2 DRS1 HCA88 PECI |
| identifier | O75521 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Isomerase Mitochondrion Peroxisome Phosphoprotein Proteomics identification Reference proteome Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ECI2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987793] ENSEMBL:ENSG00000198721 ECI2 [Homo sapiens] |
| secondaryIdentifier | ECI2_HUMAN Q5JYK5 Q5JYK7 Q7L124 Q8N0X0 Q9BUE9 Q9H0T9 Q9NQH1 Q9NYH7 Q9UN55 |
| sequenceLength | 394 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O75521-2 |
| (referenceEntity) | [EntityWithAccessionedSequence:6809809] ECI2 [peroxisomal matrix] [Homo sapiens] [EntityWithAccessionedSequence:9033094] ECI2(39-394) [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O75521-2 ECI2 (436229)
