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Details on Person UniProt:P28332-2 ADH6
| Class:Id | ReferenceIsoform:436088 |
|---|---|
| _chainChangeLog | chain:1-368 added on Fri February 6 2015 |
| _displayName | UniProt:P28332-2 ADH6 |
| _timestamp | 2025-02-21 19:24:59 |
| chain | chain:1-368 |
| checksum | EC8E81E9571E6241 |
| comment | FUNCTION Alcohol dehydrogenase (PubMed:1755855). Catalyzes the NAD-dependent oxidation of primary alcohols to the corresponding aldehydes (PubMed:1755855). Oxidizes secondary alcohols to the corresponding ketones (By similarity).CATALYTIC ACTIVITY a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)CATALYTIC ACTIVITY a secondary alcohol + NAD(+) = a ketone + NADH + H(+)COFACTOR Binds 2 Zn(2+) ions per subunit.ACTIVITY REGULATION Inhibited partially by pyrazole (10 mM) in the reaction mixture containing 100 mM ethanol at pH 10.0.BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 10.0.SUBUNIT Dimer.SUBCELLULAR LOCATION Stomach and liver.MISCELLANEOUS There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.MISCELLANEOUS Isoelectric point (pH(I)) is 8.6.SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. Class-V subfamily. |
| created | [InstanceEdit:435871] Kanapin, AA |
| description | recommendedName: Alcohol dehydrogenase 6 ecNumber evidence="3"1.1.1.1 |
| geneName | ADH6 |
| identifier | P28332 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytoplasm Metal-binding NAD Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | ADH6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991117] ENSEMBL:ENSG00000172955 ADH6 [Homo sapiens] |
| secondaryIdentifier | ADH6_HUMAN A0A0A0MS56 B3KS45 Q58F53 |
| sequenceLength | 368 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P28332-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P28332-2 ADH6 (436088)
