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Details on Person UniProt:Q8IX12-2 CCAR1
| Class:Id | ReferenceIsoform:435962 |
|---|---|
| _chainChangeLog | chain:1-1150 added on Fri February 6 2015 |
| _displayName | UniProt:Q8IX12-2 CCAR1 |
| _timestamp | 2024-11-03 20:09:11 |
| chain | chain:1-1150 |
| checksum | 30618DCC8097F552 |
| comment | FUNCTION Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938).SUBUNIT Directly interacts with ESR1, NR3C1 and p53/TP53 (By similarity). Interacts (via N-terminus) with CALCOCO1. Interacts with MED1 (By similarity). Interacts with GATA1. Interacts with AR and GATA2.INTERACTION Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence. |
| created | [InstanceEdit:435871] Kanapin, AA |
| description | recommendedName: Cell division cycle and apoptosis regulator protein 1 alternativeName: Cell cycle and apoptosis regulatory protein 1 shortName: CARP-1 alternativeName: Death inducer with SAP domain |
| geneName | CCAR1 CARP1 DIS |
| identifier | Q8IX12 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Activator Alternative splicing Apoptosis Cell cycle Coiled coil Cytoplasm Isopeptide bond Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CCAR1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997051] ENSEMBL:ENSG00000060339 CCAR1 [Homo sapiens] |
| secondaryIdentifier | CCAR1_HUMAN A0JLT7 A1L4P7 A8K9D4 B4DNP8 B4DRK8 Q32NE3 Q5EBM3 Q5VUP6 Q6PIZ0 Q6X935 Q9H8N4 Q9NVA7 Q9NVQ0 Q9NWM6 |
| sequenceLength | 1150 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q8IX12-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8IX12-2 CCAR1 (435962)
