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Details on Person UniProt:Q9Y2D5-4 PALM2AKAP2
| Class:Id | ReferenceIsoform:435873 |
|---|---|
| _chainChangeLog | chain:1-859 added on Fri February 6 2015;chain:1-859 for 435873 removed on Mon Feb 26 2024;chain:1-1103 for 435873 added on Mon Feb 26 2024 |
| _displayName | UniProt:Q9Y2D5-4 PALM2AKAP2 |
| _timestamp | 2026-02-20 22:02:42 |
| chain | chain:1-1103 |
| checksum | B501182135112FE5 |
| comment | FUNCTION Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. Binds to and modulates the structure of the actin cytoskeleton.SUBCELLULAR LOCATION Accumulates near the inner, apical surface of highly polarized epithelium in tubules of nephrons.ALTERNATIVE PRODUCTS Expressed in infantile heart and muscle, and fibroblasts.DOMAIN The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.MISCELLANEOUS Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein.MISCELLANEOUS Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:435871] Kanapin, AA |
| description | recommendedName: fullName evidence="9"PALM2-AKAP2 fusion protein alternativeName: A-kinase anchor protein 2 shortName: AKAP-2 alternativeName: AKAP-KL alternativeName: fullName evidence="1"Paralemmin A kinase anchor protein alternativeName: fullName evidence="8"Paralemmin-2 alternativeName: Protein kinase A-anchoring protein 2 shortName: PRKA2 |
| geneName | PALM2AKAP2 KIAA0920 PAKAP PALM2 |
| identifier | Q9Y2D5 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell membrane Coiled coil Glycoprotein GPI-anchor Isopeptide bond Lipoprotein Membrane Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:435871] Kanapin, AA [InstanceEdit:437306] Schmidt, EE [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | PALM2AKAP2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9862394] ENSEMBL:ENSG00000157654 PALM2AKAP2 [Homo sapiens] |
| secondaryIdentifier | PLAK2_HUMAN A9Z1X9 B1ALX9 B2RTU4 B3KQ00 B4DTZ2 B7ZW07 B9EJB5 Q8IXS6 Q8N9D5 Q96DU1 Q9UG26 |
| sequenceLength | 1103 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9Y2D5-4 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9Y2D5-4 PALM2AKAP2 (435873)
