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Details on Person UniProt:P0CAX5 Ophn1
| Class:Id | ReferenceGeneProduct:435484 |
|---|---|
| _chainChangeLog | chain:1-802 added on Fri February 6 2015 |
| _displayName | UniProt:P0CAX5 Ophn1 |
| _timestamp | 2023-11-03 15:50:33 |
| chain | chain:1-802 |
| checksum | 3CC11A730587B97A |
| comment | FUNCTION Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function, in hippocampal neurons. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre-synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation.SUBUNIT Interacts with HOMER1. Interacts with AMPA receptor complexes. Interacts with SH3GL2 (endophilin-A1). Interacts (via C-terminus) with NR1D1.SUBCELLULAR LOCATION High expression in brain, particularly in the cerebellum, hippocampus, thalamus, frontal lobes, sensory cortex. Found in the myelin sheaths of peripheral nerves, chromaffin cells within the adrenal medulla, and in extra-adrenal chromaffin cells associated with celiac ganglia. |
| created | [InstanceEdit:435478] Kanapin, AA |
| description | recommendedName: Oligophrenin-1 |
| geneName | Ophn1 |
| identifier | P0CAX5 |
| isSequenceChanged | FALSE |
| keyword | Cell projection Cytoplasm Endocytosis GTPase activation Neurogenesis Reference proteome Synapse |
| modified | [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Ophn1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | OPHN1_RAT |
| sequenceLength | 802 |
| species | [Species:48895] Rattus norvegicus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P0CAX5 Ophn1 (435484)
