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Details on Person UniProt:Q9MZ08 BCAM
| Class:Id | ReferenceGeneProduct:435479 |
|---|---|
| _chainChangeLog | signal peptide:1-31 added on Fri February 6 2015;chain:32-628 added on Fri February 6 2015 |
| _displayName | UniProt:Q9MZ08 BCAM |
| _timestamp | 2025-02-21 18:44:40 |
| chain | signal peptide:1-31 chain:32-628 |
| checksum | 2128B1F1B73E6A93 |
| comment | FUNCTION Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR.SUBUNIT Homodimer. Interacts with ITGA4:ITGB1. Interacts with spectrins SPTA1 and SPTB1.SUBCELLULAR LOCATION Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin. Ser-621 can also be phosphorylated by AKT1. |
| created | [InstanceEdit:435478] Kanapin, AA |
| description | recommendedName: Basal cell adhesion molecule alternativeName: B-CAM cell surface glycoprotein alternativeName: Lutheran antigen cdAntigenNameCD239/cdAntigenName |
| geneName | BCAM |
| identifier | Q9MZ08 |
| isSequenceChanged | FALSE |
| keyword | Cell adhesion Cell membrane Disulfide bond Glycoprotein Immunoglobulin domain Membrane Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | BCAM |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | BCAM_BOVIN |
| sequenceLength | 628 |
| species | [Species:48898] Bos taurus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9MZ08 BCAM (435479)
