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Details on Person SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol

Class:Id	Reaction:435349
_displayName	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2025-08-13 17:45:12
authored	[InstanceEdit:435367] Jassal, Bijay, 2009-09-09
catalystActivity	[CatalystActivity:435344] iron ion transmembrane transporter activity of SLC11A2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:435367] Jassal, Bijay, 2009-09-09
crossReference	[DatabaseIdentifier:9957286] RHEA:29581
edited	[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
input	[SimpleEntity:351626] H+ [extracellular region] [SimpleEntity:435347] Fe2+ [extracellular region]
literatureReference	[LiteratureReference:435376] Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells
modified	[InstanceEdit:437135] Jassal, Bijay, 2009-09-11 [InstanceEdit:442658] Jassal, Bijay, 2009-09-29 [InstanceEdit:446288] Jassal, Bijay, 2009-11-12 [InstanceEdit:446536] Jassal, Bijay, 2009-11-13 [InstanceEdit:917843] Jassal, Bijay, 2010-07-30 [InstanceEdit:5623578] Jassal, Bijay, 2014-09-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9957283] Stephan, Ralf, 2025-06-18 [InstanceEdit:9963151] Stephan, Ralf, 2025-08-13
name	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes
negativePrecedingEvent	[NegativePrecedingEvent:9963161] Futile Cycle: SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region [NegativePrecedingEvent:9963149] Futile Cycle: SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region
output	[SimpleEntity:70106] H+ [cytosol] [SimpleEntity:71067] Fe2+ [cytosol]
precedingEvent	[Reaction:917805] CYBRD1:Heme reduces Fe3+ to Fe2+ [Homo sapiens]
releaseDate	2009-12-15
reviewed	[InstanceEdit:446289] He, Lei, 2009-11-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104523] R-HSA-435349.3
summation	[Summation:435343] The primary site for absorption of dietary iron is the duode...
(hasEvent)	[Pathway:425410] Metal ion SLC transporters [Homo sapiens] [Pathway:917937] Iron uptake and transport [Homo sapiens]
(normalReaction)	[FailedReaction:5623558] Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol [Homo sapiens]
(precedingEvent)	[Reaction:435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages [Homo sapiens] [Reaction:904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region [Homo sapiens] [NegativePrecedingEvent:9963156] Futile Cycle: SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol
(updatedInstance)	[_UpdateTracker:9785647] Update Tracker - [Reaction:435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - v51:[modifyText]
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