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Details on Person Natural resistance-associated macrophage proteins (NRAMPs) r...
| Class:Id | Summation:435170 |
|---|---|
| _displayName | Natural resistance-associated macrophage proteins (NRAMPs) r... |
| _timestamp | 2025-06-18 08:03:54 |
| created | [InstanceEdit:435174] Jassal, Bijay, 2009-09-07 |
| modified | [InstanceEdit:435367] Jassal, Bijay, 2009-09-09 [InstanceEdit:442374] Jassal, Bijay, 2009-09-25 [InstanceEdit:442658] Jassal, Bijay, 2009-09-29 [InstanceEdit:445894] Jassal, B, 2009-11-06 [InstanceEdit:6807631] Shamovsky, Veronica, 2015-11-03 [InstanceEdit:9625999] Shamovsky, Veronica, 2018-10-24 [InstanceEdit:9957283] Stephan, Ralf, 2025-06-18 |
| text | Natural resistance-associated macrophage proteins (NRAMPs) regulate macrophage activation for antimicrobial activity against intracellular pathogens. They do this by mediating bivalent metal ion transport across macrophage membranes and the subsequent use of these ions in the Fenton/and or Haber–Weiss reactions of free radical formation. The human gene SLC11A1 encodes NRAMP1 (Kishi F, 2004; Kishi F and Nobumoto M, 1995) which can utilize the protonmotive force to mediate divalent iron (Fe2+), zinc (Zn2+) and manganese (Mn2+) influx to or efflux from phagosomes in an antiport mechanism (Goswami et al., 2001). |
| (summation) | [Reaction:435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages [Homo sapiens] |
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No pathways have been reviewed or authored by Natural resistance-associated macrophage proteins (NRAMPs) r... (435170)
