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Details on Person CRAC translocates calcium from the extracellular region to the cytosol

Class:Id	Reaction:434798
_displayName	CRAC translocates calcium from the extracellular region to the cytosol
_doRelease	TRUE
_timestamp	2014-02-05 03:25:17
authored	[InstanceEdit:435013] Akkerman, JW, 2009-09-04
catalystActivity	[CatalystActivity:434796] store-operated calcium channel activity of CRAC channel [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:434799] Jupe, S, 2009-09-02
edited	[InstanceEdit:870305] Jupe, S, 2010-06-07
inferredFrom	[Reaction:434802] Calcium influx via CRAC [Drosophila melanogaster]
input	[SimpleEntity:74112] Ca2+ [extracellular region]
modified	[InstanceEdit:435393] Jupe, S, 2009-09-09 [InstanceEdit:870306] Jupe, S, 2010-06-07 [InstanceEdit:1168378] May, B, 2010-12-18 [InstanceEdit:5251728] May, B, 2014-02-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CRAC translocates calcium from the extracellular region to the cytosol Calcium influx via CRAC
output	[SimpleEntity:74016] Ca2+ [cytosol]
precedingEvent	[Reaction:434700] STIM1 activation of CRAC [Homo sapiens] [Reaction:1168376] STIM1 oligomerizes [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105439] R-HSA-434798.2
summation	[Summation:434800] Activation of Calcium-release-activated (CRAC) channels allo...
(hasEvent)	[Pathway:139853] Elevation of cytosolic Ca2+ levels [Homo sapiens] [Pathway:983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers [Homo sapiens] [Pathway:5578775] Ion homeostasis [Homo sapiens]
(precedingEvent)	[Reaction:74448] Calcium binds calmodulin [Homo sapiens] [Reaction:1168373] PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine [Homo sapiens] [Reaction:2025890] Calcineurin binds NFATC1,2,3 [Homo sapiens]
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No pathways have been reviewed or authored by CRAC translocates calcium from the extracellular region to the cytosol (434798)