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Details on Person Sustained calcium signalling in lymphocytes and platelets re...

Class:IdSummation:434701
_displayNameSustained calcium signalling in lymphocytes and platelets re...
_timestamp2016-02-29 11:08:56
created[InstanceEdit:434691] Jupe, S, 2009-09-02
literatureReference[LiteratureReference:434681] Calcium signalling in lymphocyte activation and disease
[LiteratureReference:434684] R93W mutation in Orai1 causes impaired calcium influx in platelets
[LiteratureReference:434797] Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai
[LiteratureReference:434721] The STIM/Orai coupling machinery
[LiteratureReference:870201] An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice
[LiteratureReference:8862656] The neglected CRAC proteins: Orai2, Orai3, and STIM2
modified[InstanceEdit:434720] Jupe, S, 2009-09-02
[InstanceEdit:434863] Jupe, S, 2009-09-03
[InstanceEdit:870198] Jupe, S, 2010-06-02
[InstanceEdit:8862658] Jupe, Steve, 2016-02-29
textSustained calcium signalling in lymphocytes and platelets requires the uptake of extracellular calcium when intracellular stores are depleted. The process whereby intracellular calcium depletion stimulates calcium uptake is often referred to as Store-operated calcium entry (SOCE). Store depletion is sensed by stromal interaction molecule 1 (STIM1), which then translocates to the plasma membrane and associates with 2 dimers of Orai to form a calcium-release activated calcium (CRAC) channel.
(summation)[Reaction:434700] STIM1 activation of CRAC [Homo sapiens]
[Reaction:434702] Stim activation of CRAC [Drosophila melanogaster]
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