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Details on Person STIM1 activation of CRAC

Class:IdReaction:434700
_displayNameSTIM1 activation of CRAC
_doReleaseTRUE
_timestamp2016-02-29 11:08:43
authored[InstanceEdit:435013] Akkerman, JW, 2009-09-04
compartment[Compartment:876] plasma membrane
created[InstanceEdit:434691] Jupe, S, 2009-09-02
edited[InstanceEdit:870305] Jupe, S, 2010-06-07
inferredFrom
input[Complex:1168370] STIM1 Dimer [endoplasmic reticulum membrane] [Homo sapiens]
[CandidateSet:8862646] ORAI dimer [plasma membrane] [Homo sapiens]
[CandidateSet:8862646] ORAI dimer [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:1168946] Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation
[LiteratureReference:1168964] STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1
[LiteratureReference:1169000] Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation
[LiteratureReference:8862653] Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels
modified[InstanceEdit:435398] Jupe, S, 2009-09-09
[InstanceEdit:870306] Jupe, S, 2010-06-07
[InstanceEdit:1168378] May, B, 2010-12-18
[InstanceEdit:1169093] May, B, 2011-01-11
[InstanceEdit:1173222] May, B, 2011-01-21
[InstanceEdit:8862649] Jupe, Steve, 2016-02-29
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSTIM1 activation of CRAC
output[Complex:434679] CRAC channel [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2010-09-21
reviewed[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104956] R-HSA-434700.3
summation[Summation:434701] Sustained calcium signalling in lymphocytes and platelets re...
(hasEvent)[Pathway:139853] Elevation of cytosolic Ca2+ levels [Homo sapiens]
[Pathway:983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers [Homo sapiens]
(precedingEvent)[Reaction:434798] CRAC translocates calcium from the extracellular region to the cytosol [Homo sapiens]
(updatedInstance)[_UpdateTracker:9783214] Update Tracker - [Reaction:434700] STIM1 activation of CRAC - v57:[addLiteratureReference, add_removeInput, modifyText]
[_UpdateTracker:9789983] Update Tracker - [Reaction:434700] STIM1 activation of CRAC - v36:[addLiteratureReference, add_removeInput]
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