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Details on Person MATEs mediate extrusion of xenobiotics

Class:Id	Reaction:434650
_displayName	MATEs mediate extrusion of xenobiotics
_doRelease	TRUE
_timestamp	2025-08-13 17:58:24
authored	[InstanceEdit:434666] Jassal, Bijay, 2009-09-02
catalystActivity	[CatalystActivity:446610] transmembrane transporter activity of MATE1/2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:434666] Jassal, Bijay, 2009-09-02
crossReference	[DatabaseIdentifier:9958564] RHEA:72184
edited	[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
input	[SimpleEntity:351626] H+ [extracellular region] [DefinedSet:446589] MATE substrates [cytosol]
literatureReference	[LiteratureReference:434658] A human transporter protein that mediates the final excretion step for toxic organic cations [LiteratureReference:434644] Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters [LiteratureReference:434640] Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2
modified	[InstanceEdit:446288] Jassal, Bijay, 2009-11-12 [InstanceEdit:446536] Jassal, Bijay, 2009-11-13 [InstanceEdit:446601] Jassal, Bijay, 2009-11-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9958565] Stephan, Ralf, 2025-06-23 [InstanceEdit:9963189] Stephan, Ralf, 2025-08-13
name	MATEs mediate extrusion of xenobiotics
negativePrecedingEvent	[NegativePrecedingEvent:9963184] Futile Cycle: OCT1 transports organic cations into hepatic cells [NegativePrecedingEvent:9963188] Futile Cycle: OCT2 mediates tubular uptake of organic cations in the kidney [NegativePrecedingEvent:9963185] Futile Cycle: OCT3 mediates renal uptake of organic cations
output	[SimpleEntity:70106] H+ [cytosol] [DefinedSet:446597] MATE substrates [extracellular region]
releaseDate	2009-12-15
reviewed	[InstanceEdit:446289] He, Lei, 2009-11-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104234] R-HSA-434650.3
summation	[Summation:434653] The human gene family SLC47 encodes 2 multidrug and toxin ex...
(hasEvent)	[Pathway:549127] SLC-mediated transport of organic cations [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9963165] Futile Cycle: MATEs mediate extrusion of xenobiotics [NegativePrecedingEvent:9963170] Futile Cycle: MATEs mediate extrusion of xenobiotics [NegativePrecedingEvent:9963180] Futile Cycle: MATEs mediate extrusion of xenobiotics
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No pathways have been reviewed or authored by MATEs mediate extrusion of xenobiotics (434650)