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Details on Person PIAS3 SUMOylates PGR with SUMO1

Class:IdReaction:4341073
_displayNamePIAS3 SUMOylates PGR with SUMO1
_doReleaseTRUE
_timestamp2022-01-19 16:41:44
authored[InstanceEdit:4090429] May, B, 2013-08-13
catalystActivity[CatalystActivity:3232160] SUMO transferase activity of PIAS3 [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9643302] SUMO transferase activity of PIAS3 [nucleoplasm] Sumoylation of MITF and its related family members TFE3 and TFEB
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:4341066] May, B, 2013-08-18
edited[InstanceEdit:4090429] May, B, 2013-08-13
input[EntityWithAccessionedSequence:3008952] PGR [nucleoplasm] [Homo sapiens]
[Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
[Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
[Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:4341022] PIAS3 induction of PRB sumoylation represses PRB transactivation by destabilizing its retention in the nucleus
[LiteratureReference:4341078] Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells
[LiteratureReference:4341126] Mechanisms underlying the control of progesterone receptor transcriptional activity by SUMOylation
modified[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9608079] May, Bruce, 2018-05-09
[InstanceEdit:9615866] May, Bruce, 2018-08-08
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9762281] May, Bruce, 2022-01-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePIAS3 SUMOylates PGR with SUMO1
output[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:4341032] monoSUMO1-K7,K388,K531-PGR [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2018-06-12
reviewed[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09
[InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8921587] R-HSA-4341073.5
summation[Summation:4341084] PIAS3 SUMOylates PGR (Progesterone receptor, PR) at lysine-7...
(hasEvent)[Pathway:4090294] SUMOylation of intracellular receptors [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775143] Update Tracker - [Reaction:4341073] PIAS3 SUMOylates PGR with SUMO1 - v80:[add_removeOutput]
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