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Details on Person PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1

Class:IdReaction:4341016
_displayNamePIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1
_doReleaseTRUE
_timestamp2022-01-19 16:39:00
authored[InstanceEdit:4090429] May, B, 2013-08-13
catalystActivity[CatalystActivity:3247478] SUMO transferase activity of PIAS1 [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9643901] SUMO transferase activity of PIAS1 [nucleoplasm] Transcription factor Sp3 is silenced through SUMO modification by PIAS1
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:4341066] May, B, 2013-08-18
edited[InstanceEdit:4090429] May, B, 2013-08-13
input[EntityWithAccessionedSequence:4341124] NR3C2 [nucleoplasm] [Homo sapiens]
[Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
[Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
[Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
[Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:4341127] Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification
[LiteratureReference:4341101] Coactivation of the N-terminal transactivation of mineralocorticoid receptor by Ubc9
[LiteratureReference:4341102] Sumoylation and proteasomal activity determine the transactivation properties of the mineralocorticoid receptor
modified[InstanceEdit:5228465] May, B, 2014-01-12
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9608079] May, Bruce, 2018-05-09
[InstanceEdit:9615866] May, Bruce, 2018-08-08
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9762281] May, Bruce, 2022-01-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1
output[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:4341098] monoSUMO1-K89,K399,K428.K494-NR3C2 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2018-06-12
reviewed[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09
[InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8915147] R-HSA-4341016.5
summation[Summation:4341085] PIAS1 SUMOylates NR3C2 (Mineralcorticoid receptor, MR) at ly...
(hasEvent)[Pathway:4090294] SUMOylation of intracellular receptors [Homo sapiens]
(updatedInstance)[_UpdateTracker:9774977] Update Tracker - [Reaction:4341016] PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 - v80:[add_removeOutput]
[_UpdateTracker:9779157] Update Tracker - [Reaction:4341016] PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 - v66:[modifyText]
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No pathways have been reviewed or authored by PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (4341016)
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