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Details on Person Polyubiquitinated TRAF6 activates TAK1 by binding to the ubi...

Class:Id	Summation:434094
_displayName	Polyubiquitinated TRAF6 activates TAK1 by binding to the ubi...
_timestamp	2010-10-15 20:36:28
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
modified	[InstanceEdit:977264] D'Eustachio, P, 2010-10-15
text	Polyubiquitinated TRAF6 activates TAK1 by binding to the ubiquitin receptor TAB2 (also known as MAP3K7IP2). This binding leads to autophosphorylation and activation of TAK1.
(summation)	[Reaction:433950] TRAF6 recruits TAK1 kinase complex [Gallus gallus] [Reaction:433957] Activation of recruited TAK1 [Gallus gallus] [Reaction:451447] Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 [Gallus gallus] [Reaction:451463] pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex [Gallus gallus] [Reaction:573296] Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation [Gallus gallus] [Reaction:994000] Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation [Gallus gallus]
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