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Details on Person IRAK2 possibly binds to Pellino proteins

Class:Id	Reaction:434089
_displayName	IRAK2 possibly binds to Pellino proteins
_doRelease	FALSE
_timestamp	2016-07-15 23:49:07
authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
input	[CandidateSet:434082] PELLINO proteins [cytosol] [Gallus gallus] [Complex:433829] TRAF6:p-IRAK2 [plasma membrane] [Gallus gallus]
literatureReference	[LiteratureReference:450804] Characterization of Pellino2, a substrate of IRAK1 and IRAK4 [LiteratureReference:450816] Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases [LiteratureReference:450818] Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex [LiteratureReference:450820] Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner
modified	[InstanceEdit:451544] Shamovsky, V, 2010-01-05 [InstanceEdit:451969] Shamovsky, V, 2010-01-14 [InstanceEdit:571338] Shamovsky, V, 2010-04-09 [InstanceEdit:975718] Shamovsky, V, 2010-10-02 [InstanceEdit:975758] Shamovsky, V, 2010-10-04 [InstanceEdit:977265] D'Eustachio, P, 2010-10-15 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	IRAK2 possibly binds to Pellino proteins
output	[Complex:433939] pUb TRAF6: p-IRAK2: Pellino proteins [plasma membrane] [Gallus gallus]
precedingEvent	[Reaction:434084] p-IRAK2- TRAF6 dissociates from the activated chTLR complex [Gallus gallus] [Reaction:434053] TRAF6 binds to p-IRAK2 complexed with activated TLR [Gallus gallus]
reviewed	[InstanceEdit:977269] D'Eustachio, P, 2010-10-15
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:8886515] R-GGA-434089.1
summation	[Summation:975757] Pellino proteins have been implicated as mediators in mammal...
(hasEvent)	[Pathway:433822] NFkB and MAPK activation mediated by TRAF6 [Gallus gallus]
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No pathways have been reviewed or authored by IRAK2 possibly binds to Pellino proteins (434089)