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Details on Person IRAK4 recruitment to the activated TLR complexed with ligand, TIRAP and MyD88

Class:Id	Reaction:434073
_displayName	IRAK4 recruitment to the activated TLR complexed with ligand, TIRAP and MyD88
_doRelease	TRUE
_timestamp	2019-02-22 21:49:39
authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
edited	[InstanceEdit:994006] Shamovsky, V, 2010-11-05
inferredFrom	[Reaction:166082] IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex [Homo sapiens]
input	[EntityWithAccessionedSequence:433873] IRAK4 [cytosol] [Gallus gallus] [EntityWithAccessionedSequence:433873] IRAK4 [cytosol] [Gallus gallus] [Complex:433821] activated TLR hetero- or homodimer : TIRAP : MyD88 complex [plasma membrane] [Gallus gallus]
literatureReference	[LiteratureReference:434579] The avian Toll-Like receptor pathway--subtle differences amidst general conformity [LiteratureReference:165891] IRAK-4: a novel member of the IRAK family with the properties of an [LiteratureReference:446867] Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
modified	[InstanceEdit:451544] Shamovsky, V, 2010-01-05 [InstanceEdit:571340] Shamovsky, V, 2010-04-09 [InstanceEdit:975719] Shamovsky, V, 2010-10-02 [InstanceEdit:977265] D'Eustachio, P, 2010-10-15 [InstanceEdit:1004540] D'Eustachio, P, 2010-11-09 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:1094880] Shamovsky, V, 2010-11-29 [InstanceEdit:5621492] Shamovsky, V, 2014-08-29 [InstanceEdit:9638021] Shamovsky, Veronica, 2019-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IRAK4 recruitment to the activated TLR complexed with ligand, TIRAP and MyD88
output	[Complex:433831] activated TLR homo- or heterodimer : TIRAP :MyD88 :IRAK4 [plasma membrane] [Gallus gallus]
precedingEvent	[Reaction:433961] Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88 [Gallus gallus] [Reaction:434058] LPS binding to Toll like receptor 4 results in dimerization of the TLR4 associated with LY96 [Gallus gallus] [Reaction:451474] Bacterial Flagellin binds TLR5 homodimer [Gallus gallus] [Reaction:451481] TLR7 binds to recognized ligands [Gallus gallus] [Reaction:517850] TLR2-1 : TLR1-2 heterodimer binds to its ligand [Gallus gallus] [Reaction:517846] TLR2-1 :TLR1-1 binds to triacyl lipopeptide [Gallus gallus]
releaseDate	2010-12-14
reviewed	[InstanceEdit:977269] D'Eustachio, P, 2010-10-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1104430] R-GGA-434073.3
summation	[Summation:571278] Mammalian IL-1 receptor-associated kinases IRAK-1, IRAK-2 an...
(hasEvent)	[Pathway:451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane [Gallus gallus]
(precedingEvent)	[Reaction:434018] Autophosphorylation of chicken IRAK4 [Gallus gallus]
(updatedInstance)	[_UpdateTracker:9789963] Update Tracker - [Reaction:434073] IRAK4 recruitment to the activated TLR complexed with ligand, TIRAP and MyD88 - v36:[modifyText]
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