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Details on Person TRAF6 binds to p-IRAK2 complexed with activated TLR

Class:Id	Reaction:434053
_displayName	TRAF6 binds to p-IRAK2 complexed with activated TLR
_doRelease	TRUE
_timestamp	2014-08-29 17:12:23
authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
edited	[InstanceEdit:994006] Shamovsky, V, 2010-11-05
inferredFrom	[Reaction:166363] TRAF6 binds to hp- IRAK1 [Homo sapiens]
input	[EntityWithAccessionedSequence:433886] TRAF6 [cytosol] [Gallus gallus] [EntityWithAccessionedSequence:433886] TRAF6 [cytosol] [Gallus gallus] [Complex:977243] p-IRAK2 bound to the activated chicken TLR complex [plasma membrane] [Gallus gallus]
literatureReference	[LiteratureReference:450125] IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination [LiteratureReference:570877] Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control [LiteratureReference:450115] TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaB
modified	[InstanceEdit:451331] Shamovsky, V, 2010-01-05 [InstanceEdit:451948] Shamovsky, V, 2010-01-14 [InstanceEdit:571289] Shamovsky, V, 2010-04-09 [InstanceEdit:975724] Shamovsky, V, 2010-10-02 [InstanceEdit:977257] Shamovsky, V, 2010-10-15 [InstanceEdit:994006] Shamovsky, V, 2010-11-05 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:1063711] Shamovsky, V, 2010-11-25 [InstanceEdit:1094880] Shamovsky, V, 2010-11-29 [InstanceEdit:5621492] Shamovsky, V, 2014-08-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRAF6 binds to p-IRAK2 complexed with activated TLR
output	[Complex:977235] chTRAF6 bound to the activated chicken TLR complex [plasma membrane] [Gallus gallus]
precedingEvent	[Reaction:434130] IRAK4 binds to activated TLR5 or 15 [Gallus gallus] [Reaction:977238] Activated TLR5/TLR15 homodimer recruits MyD88 adaptor [Gallus gallus]
relatedSpecies	[Species:451465] Salmonella typhimurium
releaseDate	2010-12-14
reviewed	[InstanceEdit:977269] D'Eustachio, P, 2010-10-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1104231] R-GGA-434053.2
summation	[Summation:571290] There is little experimental data about mammalian IRAK2 medi...
(hasEvent)	[Pathway:433822] NFkB and MAPK activation mediated by TRAF6 [Gallus gallus]
(precedingEvent)	[Reaction:434084] p-IRAK2- TRAF6 dissociates from the activated chTLR complex [Gallus gallus]
(updatedInstance)	[_UpdateTracker:9790005] Update Tracker - [Reaction:434053] TRAF6 binds to p-IRAK2 complexed with activated TLR - v36:[modifyText]
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No pathways have been reviewed or authored by TRAF6 binds to p-IRAK2 complexed with activated TLR (434053)