Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person TBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex

Class:IdReaction:434030
_displayNameTBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex
_doReleaseTRUE
_timestamp2024-03-01 06:30:09
authored[InstanceEdit:434153] Shamovsky, V, 2009-08-26
compartment[Compartment:74700] endosome membrane
[Compartment:70101] cytosol
created[InstanceEdit:434122] Shamovsky, V, 2009-08-26
edited[InstanceEdit:668815] Shamovsky, V, 2010-05-04
inferredFrom
input[Complex:433947] viral dsRNA : TLR3 : TICAM1 [endosome membrane] [Gallus gallus]
[EntityWithAccessionedSequence:434016] TBK1 [cytosol] [Gallus gallus]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[EntityWithAccessionedSequence:434016] TBK1 [cytosol] [Gallus gallus]
literatureReference[LiteratureReference:433920] Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
[LiteratureReference:433854] Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation
modified[InstanceEdit:434393] Shamovsky, V, 2009-08-28
[InstanceEdit:434587] Shamovsky, V, 2009-08-31
[InstanceEdit:446258] Shamovsky, V, 2009-11-11
[InstanceEdit:571372] Shamovsky, V, 2010-04-09
[InstanceEdit:674740] Shamovsky, V, 2010-05-05
[InstanceEdit:796985] Shamovsky, V, 2010-05-24
[InstanceEdit:844696] Shamovsky, V, 2010-05-28
[InstanceEdit:1004540] D'Eustachio, P, 2010-11-09
[InstanceEdit:1008271] Shamovsky, V, 2010-11-10
[InstanceEdit:2581437] Shamovsky, V, 2012-11-12
[InstanceEdit:9014710] Shamovsky, Veronica, 2017-08-02
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9863525] Shamovsky, Veronica, 2024-03-01
nameTBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex
output[Complex:433843] ds viral RNA : TLR3 : TICAM1 : TBK1 complex [endosome membrane] [Gallus gallus]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
relatedSpecies[Species:9014381] Infectious bronchitis virus
releaseDate2010-12-14
reviewed[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
reviewStatus[ReviewStatus:9821382] five stars
species[Species:49591] Gallus gallus
stableIdentifier[StableIdentifier:1105715] R-GGA-434030.4
summation[Summation:433959] Upon stimulation by pathogen-associated inflammatory signals...
[Summation:571162] Chicken TBK1 protein, confirmed by transcript evidedence, sh...
(hasEvent)[Pathway:434136] Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1 [Gallus gallus]
(precedingEvent)[Reaction:433786] Phosphorylation of IRF3 by TBK1 complexed with activated TLR3 [Gallus gallus]
[Reaction:433826] Phosphorylation of IRF3 by IKK epsilon(IKBKE) complexed with activated TLR3 [Gallus gallus]
(updatedInstance)[_UpdateTracker:9786410] Update Tracker - [Reaction:434030] TBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex - v49:[modifyText]
[_UpdateTracker:9788220] Update Tracker - [Reaction:434030] TBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex - v43:[modifyText]
[_UpdateTracker:9789635] Update Tracker - [Reaction:434030] TBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex - v37:[modifyText]
[_UpdateTracker:9789898] Update Tracker - [Reaction:434030] TBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex - v36:[modifyText]
[_UpdateTracker:9846775] Update Tracker - [Reaction:434030] TBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex - v84:[modifyText]
[Change default viewing format]
No pathways have been reviewed or authored by TBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex (434030)
Follow Reactome