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Details on Person activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the phospho-IkB

Class:Id	Reaction:433986
_displayName	activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the phospho-IkB
_doRelease	TRUE
_timestamp	2011-03-10 16:24:34
authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
catalystActivity	[CatalystActivity:434081] protein serine/threonine kinase activity of activated IKKs complex [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
inferredFrom	[Reaction:193705] IKKbeta phosphorylates IkB causing NF-kB to dissociate [Homo sapiens]
input	[SimpleEntity:113592] ATP [cytosol] [Complex:434019] IkB alpha : NFkB complex [cytosol] [Gallus gallus] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases
modified	[InstanceEdit:434589] Shamovsky, V, 2009-08-31 [InstanceEdit:532633] Shamovsky, V, 2010-03-01 [InstanceEdit:571390] Shamovsky, V, 2010-04-09 [InstanceEdit:674747] Shamovsky, V, 2010-05-05 [InstanceEdit:796987] Shamovsky, V, 2010-05-24 [InstanceEdit:844697] Shamovsky, V, 2010-05-28 [InstanceEdit:1004540] D'Eustachio, P, 2010-11-09 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:1227772] Shamovsky, V, 2011-03-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the phospho-IkB
output	[Complex:434125] NFkB complex(p50/p65) [cytosol] [Gallus gallus] [SimpleEntity:29370] ADP [cytosol] [EntityWithAccessionedSequence:433842] phosphorylated IkB_alpha [cytosol] [Gallus gallus] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:433845] chicken RIP1 facilitates IKKs complex activation [Gallus gallus] [Reaction:434097] viral dsRNA:TRL3:TICAM1 activates RIP1 [Gallus gallus] [Reaction:433955] Phosphorylation of IKKs complex by activated TAK1 [Gallus gallus] [Reaction:433957] Activation of recruited TAK1 [Gallus gallus] [Reaction:451447] Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 [Gallus gallus] [Reaction:532630] p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 [Gallus gallus] [Reaction:532632] TRAF6 binds to p-IRAK2 complexed with activated TLR7 or TLR21 [Gallus gallus] [Reaction:1227783] Phosphorylation of IKKs complex mediated by MEKK1 [Gallus gallus] [Reaction:1227778] MEKK1 binds TRAF6 [Gallus gallus]
releaseDate	2010-12-14
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1105175] R-GGA-433986.2
summation	[Summation:434024] The phosphorylation and ubiquitination of IkB kinase complex...
(hasEvent)	[Pathway:434001] TAK1 activates NFkB by phosphorylation and activation of IKKs complex [Gallus gallus] [Pathway:434131] NFkB activation mediated by RIP1 complexed with activated TLR3 [Gallus gallus] [Pathway:1227892] TRAF6 mediated NF-kB activation [Gallus gallus]
(precedingEvent)	[Reaction:433823] Released NFkB complex migrates to the nucleus and turns on transcription [Gallus gallus]
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No pathways have been reviewed or authored by activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the phospho-IkB (433986)