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Details on Person Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88

Class:Id	Reaction:433961
_displayName	Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88
_doRelease	TRUE
_timestamp	2019-02-22 21:49:11
authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
edited	[InstanceEdit:994006] Shamovsky, V, 2010-11-05
inferredFrom	[Reaction:166072] MyD88 forms a complex with TIRAP:activated TLR2/4 [Homo sapiens]
input	[EntityWithAccessionedSequence:433987] MyD88 [cytosol] [Gallus gallus] [EntityWithAccessionedSequence:433987] MyD88 [cytosol] [Gallus gallus] [EntityWithAccessionedSequence:433807] TIRAP [cytosol] [Gallus gallus] [EntityWithAccessionedSequence:433807] TIRAP [cytosol] [Gallus gallus] [DefinedSet:451517] activated TLR2 or 4 bound to ligand [plasma membrane] [Gallus gallus]
isChimeric	FALSE
literatureReference	[LiteratureReference:571177] Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88) [LiteratureReference:177881] Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway [LiteratureReference:166234] The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors [LiteratureReference:571295] Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases
modified	[InstanceEdit:451539] Shamovsky, V, 2010-01-05 [InstanceEdit:571294] Shamovsky, V, 2010-04-09 [InstanceEdit:975713] Shamovsky, V, 2010-10-02 [InstanceEdit:977266] D'Eustachio, P, 2010-10-15 [InstanceEdit:1004540] D'Eustachio, P, 2010-11-09 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:1094365] Shamovsky, V, 2010-11-29 [InstanceEdit:5621492] Shamovsky, V, 2014-08-29 [InstanceEdit:9638021] Shamovsky, Veronica, 2019-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88
output	[Complex:433821] activated TLR hetero- or homodimer : TIRAP : MyD88 complex [plasma membrane] [Gallus gallus]
precedingEvent	[Reaction:434058] LPS binding to Toll like receptor 4 results in dimerization of the TLR4 associated with LY96 [Gallus gallus] [Reaction:434003] LPS binding to CD14 co-receptor [Gallus gallus] [Reaction:451474] Bacterial Flagellin binds TLR5 homodimer [Gallus gallus] [Reaction:451481] TLR7 binds to recognized ligands [Gallus gallus] [Reaction:517850] TLR2-1 : TLR1-2 heterodimer binds to its ligand [Gallus gallus] [Reaction:517846] TLR2-1 :TLR1-1 binds to triacyl lipopeptide [Gallus gallus]
releaseDate	2010-12-14
reviewed	[InstanceEdit:977269] D'Eustachio, P, 2010-10-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1105467] R-GGA-433961.3
summation	[Summation:571170] Cloning and analysis of full length chicken MyD88 revealed a...
(hasEvent)	[Pathway:451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane [Gallus gallus]
(precedingEvent)	[Reaction:434073] IRAK4 recruitment to the activated TLR complexed with ligand, TIRAP and MyD88 [Gallus gallus]
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No pathways have been reviewed or authored by Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88 (433961)