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Details on Person Upon stimulation by pathogen-associated inflammatory signals...

Class:Id	Summation:433959
_displayName	Upon stimulation by pathogen-associated inflammatory signals...
_timestamp	2023-01-12 03:55:50
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
literatureReference	[LiteratureReference:433880] Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes [LiteratureReference:5362581] Crystal structure and mechanism of activation of TANK-binding kinase 1 [LiteratureReference:5362611] Structure and ubiquitination-dependent activation of TANK-binding kinase 1 [LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway [LiteratureReference:165917] The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection [LiteratureReference:433854] Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation [LiteratureReference:933502] NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase [LiteratureReference:933515] Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK [LiteratureReference:5362506] Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF [LiteratureReference:5362609] SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK [LiteratureReference:5362586] Functional dissection of the TBK1 molecular network
modified	[InstanceEdit:434393] Shamovsky, V, 2009-08-28 [InstanceEdit:434588] Shamovsky, V, 2009-08-31 [InstanceEdit:674743] Shamovsky, V, 2010-05-05 [InstanceEdit:975771] Shamovsky, V, 2010-10-04 [InstanceEdit:977264] D'Eustachio, P, 2010-10-15 [InstanceEdit:1227992] Shamovsky, V, 2011-03-16 [InstanceEdit:2559488] Shamovsky, V, 2012-11-02 [InstanceEdit:5362622] Shamovsky, V, 2014-04-16 [InstanceEdit:9823929] Shamovsky, Veronica, 2023-01-12
text	Upon stimulation by pathogen-associated inflammatory signals, TANK-binding kinase 1 (TBK1) and inhibitor of kappaB kinase epsilon (IKKi, IKBKE) induce type I interferon expression and modulate nuclear factor kappa-B (NF-kappa-B) signaling (Fitzgerald KA et al. 2003; Hemmi H et al. 2004). The structural studies of TBK1 revealed a dimeric assembly which is mediated by several interfaces involving kinase domain (KD), a ubiquitin-like domain (ULD), and an alpha-helical scaffold dimerization domain (SDD) of TBK1 (Larabi A et al. 2013; Tu D et al. 2013). ULD of TBK1 (and IKBKE) was involved in the control of kinase activation, substrate presentation and downstream signaling (Ikeda F et al 2007; Tu D et al. 2013). An intact TBK1 dimer was a subject to K63-linked polyubiquitination on lysines 30 and 401 (Tu D et al. 2013). Activation of TBK1 rearranged the KD into an active conformation while maintaining the overall dimer conformation (Larabi A et al. 2013). The ubiquitination sites and dimer contacts are conserved in the close homolog IKBKE (Tu D et al. 2013). The activation of TBK1 and IKKi may occur through autophosphorylation or via activity of a distinct protein kinase (Clark et al. 2009). Other studies demonstrated an essential role of TRAF3 in the activation of TBK1 (Hacker et al 2006). TBK1 and IKBKE were found to interact with scaffold proteins TANK (TRAF family member associated NFkB activator), NAP1 (NAK-associated protein 1), SINTBAD (similar to NAP1 TBK1 adaptor) which connect TBK1/IKBKE to pathogen-activated signaling cascades (Pomerantz JL and Baltimore D 1999; Guo B and Cheng G 2007; Gatot JC et al. 2007; Ryzhakov G and Randow F 2007; Goncalves A et al. 2011).
(summation)	[Reaction:433804] IKK epsilon is recruited to the Viral dsRNA:TLR3:TICAM1 complex [Gallus gallus] [Reaction:434030] TBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex [Gallus gallus] [Reaction:936941] Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation [Homo sapiens]
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No pathways have been reviewed or authored by Upon stimulation by pathogen-associated inflammatory signals... (433959)