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Details on Person Activation of recruited TAK1

Class:Id	Reaction:433957
_displayName	Activation of recruited TAK1
_doRelease	TRUE
_timestamp	2017-09-25 21:20:10
authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
catalystActivity	[CatalystActivity:434006] protein serine/threonine kinase activity of viral dsRNA : TLR3 : TICAM1 : pUb_TRAF6 :TAB2 :TAB3: TAK1 : TAB1: free_pUb_chain [endosome membrane]
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
edited	[InstanceEdit:2272816] Shamovsky, V, 2012-05-25
inferredFrom	[Reaction:177692] Activation of recruited TAK1 within the activated TLR3 complex [Homo sapiens]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:434146] viral dsRNA : TLR3 : TICAM1 : pUb_TRAF6 :TAB2 :TAB3: TAK1 : TAB1: free_pUb_chain [endosome membrane] [Gallus gallus]
literatureReference	[LiteratureReference:571311] PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1 [LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK [LiteratureReference:208156] TAK1 is a ubiquitin-dependent kinase of MKK and IKK [LiteratureReference:433972] TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
modified	[InstanceEdit:434465] Shamovsky, V, 2009-08-30 [InstanceEdit:434572] Shamovsky, V, 2009-08-31 [InstanceEdit:442976] Shamovsky, V, 2009-09-29 [InstanceEdit:446248] Shamovsky, V, 2009-11-11 [InstanceEdit:451539] Shamovsky, V, 2010-01-05 [InstanceEdit:451965] Shamovsky, V, 2010-01-14 [InstanceEdit:571304] Shamovsky, V, 2010-04-09 [InstanceEdit:674711] Shamovsky, V, 2010-05-05 [InstanceEdit:796980] Shamovsky, V, 2010-05-24 [InstanceEdit:844693] Shamovsky, V, 2010-05-28 [InstanceEdit:1004540] D'Eustachio, P, 2010-11-09 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:2272815] Shamovsky, V, 2012-05-25 [InstanceEdit:2272818] Shamovsky, V, 2012-05-25 [InstanceEdit:9014710] Shamovsky, Veronica, 2017-08-02 [InstanceEdit:9022893] Shamovsky, Veronica, 2017-09-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activation of recruited TAK1
output	[SimpleEntity:29370] ADP [cytosol] [Complex:434152] viral dsRNA : TLR3 : TICAM1 : pUb_TRAF6 :TAB2:TAB3 :phospho TAK1 : TAB1 : free pUb chain [endosome membrane] [Gallus gallus] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:433950] TRAF6 recruits TAK1 kinase complex [Gallus gallus] [BlackBoxEvent:433936] Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1 [Gallus gallus]
relatedSpecies	[Species:9014381] Infectious bronchitis virus
releaseDate	2010-12-14
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1104531] R-GGA-433957.4
summation	[Summation:434094] Polyubiquitinated TRAF6 activates TAK1 by binding to the ubi... [Summation:446239] Chicken TAK1 complex proteins TAK1, TAB1, TAB2 and TAB3, con...
(hasEvent)	[Pathway:433871] TRAF6 mediated induction of proinflammatory cytokines [Gallus gallus]
(precedingEvent)	[Reaction:433955] Phosphorylation of IKKs complex by activated TAK1 [Gallus gallus] [Reaction:437984] Phosphorylation of MKK3/MKK6 by activated TAK1 [Gallus gallus] [Reaction:437999] Phosphorylation of MKK4 by activated TAK1 [Gallus gallus] [Reaction:921145] Activated chicken TAK1 dissociates from the activated TLR3 complex [Gallus gallus]
(updatedInstance)	[_UpdateTracker:9789969] Update Tracker - [Reaction:433957] Activation of recruited TAK1 - v36:[modifyText]
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No pathways have been reviewed or authored by Activation of recruited TAK1 (433957)