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Details on Person TRAF6 recruits TAK1 kinase complex

Class:Id	Reaction:433950
_displayName	TRAF6 recruits TAK1 kinase complex
_doRelease	TRUE
_timestamp	2017-09-25 21:24:41
authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
edited	[InstanceEdit:2272815] Shamovsky, V, 2012-05-25
inferredFrom	[Reaction:177690] Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex [Homo sapiens]
input	[Complex:433839] TAK1 : TAB1 : TAB2/TAB3 complex [cytosol] [Gallus gallus] [Complex:433839] TAK1 : TAB1 : TAB2/TAB3 complex [cytosol] [Gallus gallus] [Complex:434102] viral ds RNA : TLR3 : TICAM1 : pUb-TRAF6 [endosome membrane] [Gallus gallus] [Polymer:451962] free K63_polyubiquitin chain [cytosol] [Gallus gallus] [Polymer:451962] free K63_polyubiquitin chain [cytosol] [Gallus gallus]
literatureReference	[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains [LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK
modified	[InstanceEdit:434588] Shamovsky, V, 2009-08-31 [InstanceEdit:446260] Shamovsky, V, 2009-11-11 [InstanceEdit:451584] Shamovsky, V, 2010-01-05 [InstanceEdit:451977] Shamovsky, V, 2010-01-14 [InstanceEdit:571384] Shamovsky, V, 2010-04-09 [InstanceEdit:674743] Shamovsky, V, 2010-05-05 [InstanceEdit:796985] Shamovsky, V, 2010-05-24 [InstanceEdit:844696] Shamovsky, V, 2010-05-28 [InstanceEdit:1004540] D'Eustachio, P, 2010-11-09 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:2272816] Shamovsky, V, 2012-05-25 [InstanceEdit:2272819] Shamovsky, V, 2012-05-25 [InstanceEdit:9014710] Shamovsky, Veronica, 2017-08-02 [InstanceEdit:9022900] Shamovsky, Veronica, 2017-09-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRAF6 recruits TAK1 kinase complex
output	[Complex:434146] viral dsRNA : TLR3 : TICAM1 : pUb_TRAF6 :TAB2 :TAB3: TAK1 : TAB1: free_pUb_chain [endosome membrane] [Gallus gallus]
precedingEvent	[BlackBoxEvent:433936] Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1 [Gallus gallus] [BlackBoxEvent:433981] Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6 [Gallus gallus]
relatedSpecies	[Species:9014381] Infectious bronchitis virus
releaseDate	2010-12-14
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1104977] R-GGA-433950.4
summation	[Summation:434094] Polyubiquitinated TRAF6 activates TAK1 by binding to the ubi...
(hasEvent)	[Pathway:433871] TRAF6 mediated induction of proinflammatory cytokines [Gallus gallus]
(precedingEvent)	[Reaction:433957] Activation of recruited TAK1 [Gallus gallus]
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No pathways have been reviewed or authored by TRAF6 recruits TAK1 kinase complex (433950)