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Details on Person Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1

Class:Id	BlackBoxEvent:433936
_displayName	Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1
_doRelease	TRUE
_timestamp	2019-02-22 21:49:16
authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
catalystActivity	[CatalystActivity:433906] ubiquitin-protein transferase activity of viral ds RNA : TLR3 : TICAM1 : pUb-TRAF6 [endosome membrane]
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
goBiologicalProcess	[GO_BiologicalProcess:436928] free ubiquitin chain polymerization
inferredFrom	[Polymerisation:450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation [Homo sapiens]
input	[DefinedSet:434147] Ubiquitin [cytosol] [Gallus gallus] [DefinedSet:434147] Ubiquitin [cytosol] [Gallus gallus] [DefinedSet:434147] Ubiquitin [cytosol] [Gallus gallus]
literatureReference	[LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK [LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains [LiteratureReference:444058] Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling [LiteratureReference:451472] TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway
modified	[InstanceEdit:434466] Shamovsky, V, 2009-08-30 [InstanceEdit:442976] Shamovsky, V, 2009-09-29 [InstanceEdit:446257] Shamovsky, V, 2009-11-11 [InstanceEdit:451539] Shamovsky, V, 2010-01-05 [InstanceEdit:451963] Shamovsky, V, 2010-01-14 [InstanceEdit:571301] Shamovsky, V, 2010-04-09 [InstanceEdit:674709] Shamovsky, V, 2010-05-05 [InstanceEdit:680254] Shamovsky, V, 2010-05-05 [InstanceEdit:796980] Shamovsky, V, 2010-05-24 [InstanceEdit:844693] Shamovsky, V, 2010-05-28 [InstanceEdit:1004540] D'Eustachio, P, 2010-11-09 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:2581437] Shamovsky, V, 2012-11-12 [InstanceEdit:9638021] Shamovsky, Veronica, 2019-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1
output	[Polymer:451962] free K63_polyubiquitin chain [cytosol] [Gallus gallus]
precedingEvent	[BlackBoxEvent:433981] Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6 [Gallus gallus] [Reaction:433808] viral dsRNA: TLR3: TICAM1 recruits TRAF6 [Gallus gallus]
relatedSpecies	[Species:9014381] Infectious bronchitis virus
releaseDate	2010-12-14
requiredInputComponent	[EntityWithAccessionedSequence:434105] UBE2V1 [cytosol] [Gallus gallus] [EntityWithAccessionedSequence:433933] Ubiquitin carier protein (UBC13 homolog) [cytosol] [Gallus gallus]
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1105611] R-GGA-433936.3
summation	[Summation:446233] TRAF6 generates unanchored Lys63-linked polyubiquitin chains...
(hasEvent)	[Pathway:433871] TRAF6 mediated induction of proinflammatory cytokines [Gallus gallus]
(precedingEvent)	[Reaction:433950] TRAF6 recruits TAK1 kinase complex [Gallus gallus]
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No pathways have been reviewed or authored by Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1 (433936)