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Details on Person RIP1 is recruited to the activated TLR receptor by binding t...

Class:IdSummation:433930
_displayNameRIP1 is recruited to the activated TLR receptor by binding t...
_timestamp2017-07-26 05:43:24
created[InstanceEdit:434122] Shamovsky, V, 2009-08-26
literatureReference[LiteratureReference:433849] Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation
[LiteratureReference:937071] NF-kappaB protects macrophages from lipopolysaccharide-induced cell death: the role of caspase 8 and receptor-interacting protein
[LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
[LiteratureReference:2569072] cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)
[LiteratureReference:165954] RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B
modified[InstanceEdit:450362] Shamovsky, V, 2009-12-16
[InstanceEdit:937107] Shamovsky, V, 2010-08-25
[InstanceEdit:977264] D'Eustachio, P, 2010-10-15
[InstanceEdit:2559478] Shamovsky, V, 2012-11-02
[InstanceEdit:2584572] Shamovsky, V, 2012-11-14
[InstanceEdit:2585258] Shamovsky, V, 2012-11-15
[InstanceEdit:9013846] Shamovsky, Veronica, 2017-07-26
textRIP1 is recruited to the activated TLR receptor by binding to TICAM1(TRIF) via its RHIM motif, followed by its polyubiquitination. Polyubiquitination is possibly mediated by TRAF6 that is also recruited to TICAM1 (Cusson-Hermance N et al. 2005). Other E3-ubiquitin ligases - cIAP1 and cIAP2 - have been reported to promote polyubiquitination of RIP proteins (Bertrand MJM et al. 2011).

RIP3 was shown to inhibit TRIF-induced NFkB activation in dose-dependent manner when overexpressed in HEK293T cells by competing with TRIF to bind RIP1 (Meylan E et al. 2004).

(summation)[Reaction:168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 [Homo sapiens]
[Reaction:168930] Viral dsRNA:TLR3:TRIF complex recruits RIP1 [Homo sapiens]
[Reaction:434097] viral dsRNA:TRL3:TICAM1 activates RIP1 [Gallus gallus]
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