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Details on Person Receptor-interacting protein 1 (RIP1) mediates the activatio...
| Class:Id | Summation:433877 |
|---|---|
| _displayName | Receptor-interacting protein 1 (RIP1) mediates the activatio... |
| _timestamp | 2012-11-14 21:23:50 |
| created | [InstanceEdit:434122] Shamovsky, V, 2009-08-26 |
| modified | [InstanceEdit:939818] Shamovsky, V, 2010-09-01 [InstanceEdit:977264] D'Eustachio, P, 2010-10-15 [InstanceEdit:1455314] D'Eustachio, P, 2011-07-19 [InstanceEdit:2584572] Shamovsky, V, 2012-11-14 |
| text | Receptor-interacting protein 1 (RIP1) mediates the activation of proinflammatory cytokines via intermediate induction of IKK complex in NFkB pathways [Ea et al. 2006]. Poly(I-C) treatment stimulated the recruitment of RIP1, TRAF6, and TAK1 to the TLR3 receptor complex in human embryonic kidney HEK293 transfected with FLAG-tagged TLR3 [Cusson-Hermance et al. 2005]. RIP1 was shown to be dispensable for TRIF-dependent activation of IRF3, which occurs in a TRIF/TBK1/IKKi-dependent manner [Cusson-Hermance et al. 2005, Sato et al. 2003] |
| (summation) | [Pathway:434131] NFkB activation mediated by RIP1 complexed with activated TLR3 [Gallus gallus] [Pathway:937041] IKK complex recruitment mediated by RIP1 [Homo sapiens] |
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No pathways have been reviewed or authored by Receptor-interacting protein 1 (RIP1) mediates the activatio... (433877)
