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Details on Person IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88

Class:Id	Reaction:433864
_displayName	IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88
_doRelease	TRUE
_timestamp	2019-02-22 21:49:33
authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
edited	[InstanceEdit:994006] Shamovsky, V, 2010-11-05
inferredFrom	[Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex [Homo sapiens]
input	[EntityWithAccessionedSequence:434068] IRAK2 [cytosol] [Gallus gallus] [EntityWithAccessionedSequence:434068] IRAK2 [cytosol] [Gallus gallus] [Complex:434022] activated TLR : TIRAP : MyD88 ; p-IRAK4 [plasma membrane] [Gallus gallus]
literatureReference	[LiteratureReference:434579] The avian Toll-Like receptor pathway--subtle differences amidst general conformity [LiteratureReference:446698] Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2
modified	[InstanceEdit:451544] Shamovsky, V, 2010-01-05 [InstanceEdit:451969] Shamovsky, V, 2010-01-14 [InstanceEdit:571336] Shamovsky, V, 2010-04-09 [InstanceEdit:975717] Shamovsky, V, 2010-10-02 [InstanceEdit:977265] D'Eustachio, P, 2010-10-15 [InstanceEdit:1004540] D'Eustachio, P, 2010-11-09 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:1094880] Shamovsky, V, 2010-11-29 [InstanceEdit:5621492] Shamovsky, V, 2014-08-29 [InstanceEdit:9638021] Shamovsky, Veronica, 2019-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88
output	[Complex:434002] IRAK2 : p-IRAK4 :MyD88 : TIRAP : activated TLR [plasma membrane] [Gallus gallus]
precedingEvent	[Reaction:434018] Autophosphorylation of chicken IRAK4 [Gallus gallus] [Reaction:434073] IRAK4 recruitment to the activated TLR complexed with ligand, TIRAP and MyD88 [Gallus gallus]
releaseDate	2010-12-14
reviewed	[InstanceEdit:977269] D'Eustachio, P, 2010-10-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1104425] R-GGA-433864.3
summation	[Summation:570878] In mammals activated IRAK4 phosphorylates both IRAK1 and IRA...
(hasEvent)	[Pathway:451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane [Gallus gallus]
(precedingEvent)	[Reaction:434047] phosphorylation of IRAK2 by activated IRAK4 [Gallus gallus]
(updatedInstance)	[_UpdateTracker:9789925] Update Tracker - [Reaction:433864] IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88 - v36:[modifyText]
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No pathways have been reviewed or authored by IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88 (433864)