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Details on Person IRF-3 is activated by two step phosphorylation. IKK related ...
| Class:Id | Summation:433848 |
|---|---|
| _displayName | IRF-3 is activated by two step phosphorylation. IKK related ... |
| _timestamp | 2011-05-23 20:19:24 |
| created | [InstanceEdit:434122] Shamovsky, V, 2009-08-26 |
| literatureReference | [LiteratureReference:434579] The avian Toll-Like receptor pathway--subtle differences amidst general conformity [LiteratureReference:434014] Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch |
| modified | [InstanceEdit:434578] Shamovsky, V, 2009-08-31 [InstanceEdit:674727] Shamovsky, V, 2010-05-05 [InstanceEdit:977265] D'Eustachio, P, 2010-10-15 [InstanceEdit:1237397] Shamovsky, V, 2011-03-30 [InstanceEdit:1267861] Shamovsky, V, 2011-05-09 [InstanceEdit:1300654] Shamovsky, V, 2011-05-23 |
| text | IRF-3 is activated by two step phosphorylation. IKK related kinases TBK1 and/or IKKi mediate the phosphorylation of the residues Ser386 and/or Ser385 (site1) and a cluster of serine/threonine residues between Ser396 and Ser405 (site 2) [Panne et al 2007]. Phosphorylation of residues in site 2 alleviates autoinhibition to allow interaction with CBP (CREB-binding protein) and facilitates phosphorylation at site 1. Phosphorylation at site 1 is required for IRF-3 dimerization. All serine residues mentioned above were empirically defined for human IRF3. Multiple sequence alignment of human, mouse and chicken IRF3 by ClustalW showed similarity in the C-terminal domain and the following chicken residues are predicted to be involved in chicken IRF3 activation:
|
| (summation) | [Reaction:433786] Phosphorylation of IRF3 by TBK1 complexed with activated TLR3 [Gallus gallus] [Reaction:433826] Phosphorylation of IRF3 by IKK epsilon(IKBKE) complexed with activated TLR3 [Gallus gallus] [Reaction:1227881] Phosphorylation and release of IRF3 [Gallus gallus] |
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