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Details on Person chicken RIP1 facilitates IKKs complex activation

Class:Id	Reaction:433845
_displayName	chicken RIP1 facilitates IKKs complex activation
_doRelease	TRUE
_timestamp	2010-12-02 14:37:46
authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
catalystActivity	[CatalystActivity:434076] protein serine/threonine kinase activity of Activated chicken TAK1 complexes [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
inferredFrom	[Reaction:168910] RIP1 facilitates IKK complex phosphorylation [Homo sapiens]
input	[Complex:434005] IKKs_complex (Inhibitor of kappa B kinases) [cytosol] [Gallus gallus] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:433849] Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation [LiteratureReference:434140] IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program [LiteratureReference:202538] The two NF-kappaB activation pathways and their role in innate and adaptive immunity [LiteratureReference:434149] The nemo binding domains of both IKKalpha and IKKbeta regulate IKK complex assembly and classical NFkappaB activation
modified	[InstanceEdit:571365] Shamovsky, V, 2010-04-09 [InstanceEdit:674731] Shamovsky, V, 2010-05-05 [InstanceEdit:796984] Shamovsky, V, 2010-05-24 [InstanceEdit:844695] Shamovsky, V, 2010-05-28 [InstanceEdit:975730] Shamovsky, V, 2010-10-02 [InstanceEdit:977264] D'Eustachio, P, 2010-10-15 [InstanceEdit:977267] D'Eustachio, P, 2010-10-15 [InstanceEdit:1004540] D'Eustachio, P, 2010-11-09 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:1063712] Shamovsky, V, 2010-11-25 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	chicken RIP1 facilitates IKKs complex activation
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:433938] activated IKKs complex [cytosol] [Gallus gallus]
precedingEvent	[Reaction:434097] viral dsRNA:TRL3:TICAM1 activates RIP1 [Gallus gallus] [Reaction:433815] viral dsRNA : TRL3 recruits TICAM1 [Gallus gallus]
regulatedBy	[PositiveRegulation:975685] Positive regulation by 'viral dsRNA : TLR3 : TICAM1 : RIP1 [endosome membrane]'
releaseDate	2010-12-14
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1105106] R-GGA-433845.3
summation	[Summation:433894] The IKKs - IkB kinase (IKK) complex serves as the master re...
(hasEvent)	[Pathway:434131] NFkB activation mediated by RIP1 complexed with activated TLR3 [Gallus gallus]
(precedingEvent)	[Reaction:433986] activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the phospho-IkB [Gallus gallus]
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No pathways have been reviewed or authored by chicken RIP1 facilitates IKKs complex activation (433845)