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Details on Person TICAM1 (or TRIF) is known to be an essential and exclusive a...
| Class:Id | Summation:433827 |
|---|---|
| _displayName | TICAM1 (or TRIF) is known to be an essential and exclusive a... |
| _timestamp | 2010-10-15 20:36:29 |
| created | [InstanceEdit:434122] Shamovsky, V, 2009-08-26 |
| literatureReference | [LiteratureReference:177881] Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway |
| modified | [InstanceEdit:434378] Shamovsky, V, 2009-08-28 [InstanceEdit:434379] Shamovsky, V, 2009-08-28 [InstanceEdit:450361] Shamovsky, V, 2009-12-16 [InstanceEdit:674741] Shamovsky, V, 2010-05-05 [InstanceEdit:977264] D'Eustachio, P, 2010-10-15 |
| text | TICAM1 (or TRIF) is known to be an essential and exclusive adaptor used by TLR3 ; all the poly(I:C)-induced pathways leading to NFkB and IRF3 activation were abolished in TRIF–/– mice (Yamamoto et al. 2003). Human TICAM1 consists of an N-terminal region (1–234), a TIR domain (235–500), and a C-terminal region (501–680). The N-terminal region of TICAM1 harbors TRAF (TNF receptor associated factor) family proteins and forms complexes containing IRF-3 and/or NFkB -activating kinases. The C-terminal region of TICAM1 can recruit receptor-interacting protein-1 (RIP-1), and this event is followed by the activation of IKK complex . |
| (summation) | [Reaction:433815] viral dsRNA : TRL3 recruits TICAM1 [Gallus gallus] |
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