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Details on Person Released NFkB complex migrates to the nucleus and turns on transcription

Class:Id	Reaction:433823
_displayName	Released NFkB complex migrates to the nucleus and turns on transcription
_doRelease	TRUE
_timestamp	2010-12-02 14:35:59
authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm [Compartment:13231] nuclear envelope
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
inferredFrom	[Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus [Homo sapiens]
input	[Complex:434125] NFkB complex(p50/p65) [cytosol] [Gallus gallus]
literatureReference	[LiteratureReference:202539] Signaling to NF-kappaB [LiteratureReference:202538] The two NF-kappaB activation pathways and their role in innate and adaptive immunity [LiteratureReference:202509] Ubiquitin signalling in the NF-kappaB pathway
modified	[InstanceEdit:434586] Shamovsky, V, 2009-08-31 [InstanceEdit:451553] Shamovsky, V, 2010-01-05 [InstanceEdit:571370] Shamovsky, V, 2010-04-09 [InstanceEdit:674738] Shamovsky, V, 2010-05-05 [InstanceEdit:749440] Shamovsky, V, 2010-05-18 [InstanceEdit:749444] Shamovsky, V, 2010-05-18 [InstanceEdit:796985] Shamovsky, V, 2010-05-24 [InstanceEdit:844696] Shamovsky, V, 2010-05-28 [InstanceEdit:1004540] D'Eustachio, P, 2010-11-09 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Released NFkB complex migrates to the nucleus and turns on transcription
output	[Complex:433908] NFkB complex(p50/p65) [nucleoplasm] [Gallus gallus]
precedingEvent	[Reaction:433986] activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the phospho-IkB [Gallus gallus] [Reaction:433845] chicken RIP1 facilitates IKKs complex activation [Gallus gallus] [Reaction:433955] Phosphorylation of IKKs complex by activated TAK1 [Gallus gallus] [Reaction:532630] p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 [Gallus gallus] [Reaction:1227783] Phosphorylation of IKKs complex mediated by MEKK1 [Gallus gallus]
releaseDate	2010-12-14
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1104809] R-GGA-433823.2
summation	[Summation:433791] NFkB is a family of transcription factors that play pivotal ... [Summation:571159] Chicken NFkB p105 (precursor of p50) subunit and NFkB p65 su...
(hasEvent)	[Pathway:434001] TAK1 activates NFkB by phosphorylation and activation of IKKs complex [Gallus gallus] [Pathway:434131] NFkB activation mediated by RIP1 complexed with activated TLR3 [Gallus gallus]
(updatedInstance)	[_UpdateTracker:9774780] Update Tracker - [Reaction:433823] Released NFkB complex migrates to the nucleus and turns on transcription - v81:[modifyText] [_UpdateTracker:9788185] Update Tracker - [Reaction:433823] Released NFkB complex migrates to the nucleus and turns on transcription - v43:[modifyText]
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