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Details on Person Phosphorylation of IRF3 by TBK1 complexed with activated TLR3

Class:Id	Reaction:433786
_displayName	Phosphorylation of IRF3 by TBK1 complexed with activated TLR3
_doRelease	TRUE
_timestamp	2012-11-12 23:53:06
authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
catalystActivity	[CatalystActivity:433910] protein serine/threonine kinase activity of ds viral RNA : TLR3 : TICAM1 : TBK1 complex [endosome membrane]
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
inferredFrom	[Reaction:166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex [Homo sapiens]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [EntityWithAccessionedSequence:433993] IRF3 [cytosol] [Gallus gallus]
literatureReference	[LiteratureReference:433975] Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300 [LiteratureReference:434014] Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch [LiteratureReference:165924] Identification of Ser-386 of interferon regulatory factor 3 as critical
modified	[InstanceEdit:434393] Shamovsky, V, 2009-08-28 [InstanceEdit:434586] Shamovsky, V, 2009-08-31 [InstanceEdit:451548] Shamovsky, V, 2010-01-05 [InstanceEdit:571367] Shamovsky, V, 2010-04-09 [InstanceEdit:674734] Shamovsky, V, 2010-05-05 [InstanceEdit:796984] Shamovsky, V, 2010-05-24 [InstanceEdit:844695] Shamovsky, V, 2010-05-28 [InstanceEdit:1004540] D'Eustachio, P, 2010-11-09 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:2581437] Shamovsky, V, 2012-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of IRF3 by TBK1 complexed with activated TLR3
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [EntityWithAccessionedSequence:434100] phosphorylated IRF3 [cytosol] [Gallus gallus]
precedingEvent	[Reaction:434030] TBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex [Gallus gallus] [Reaction:433815] viral dsRNA : TRL3 recruits TICAM1 [Gallus gallus] [Reaction:433804] IKK epsilon is recruited to the Viral dsRNA:TLR3:TICAM1 complex [Gallus gallus] [Reaction:433815] viral dsRNA : TRL3 recruits TICAM1 [Gallus gallus]
releaseDate	2010-12-14
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1105730] R-GGA-433786.2
summation	[Summation:433848] IRF-3 is activated by two step phosphorylation. IKK related ...
(hasEvent)	[Pathway:434136] Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1 [Gallus gallus]
(precedingEvent)	[Reaction:434027] Dimerization of Phospho-IRF3 [Gallus gallus]
(updatedInstance)	[_UpdateTracker:9789562] Update Tracker - [Reaction:433786] Phosphorylation of IRF3 by TBK1 complexed with activated TLR3 - v37:[modifyText]
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