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Details on Person SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol

Class:Id	Reaction:433698
_displayName	SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2025-08-13 18:09:03
authored	[InstanceEdit:433709] Jassal, Bijay, 2009-08-25
catalystActivity	[CatalystActivity:434169] monocarboxylic acid transmembrane transporter activity of SLC16A7:EMB,SLC16A3,8:BSG [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:433709] Jassal, Bijay, 2009-08-25
crossReference	[DatabaseIdentifier:9861793] RHEA:29417 [DatabaseIdentifier:9861914] RHEA:64721
edited	[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
input	[SimpleEntity:351626] H+ [extracellular region] [DefinedSet:433683] MCT substrates [extracellular region]
literatureReference	[LiteratureReference:373885] Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter [LiteratureReference:433697] Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2 [LiteratureReference:445737] Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells [LiteratureReference:8959772] Monocarboxylic acid transport
modified	[InstanceEdit:434163] Jassal, Bijay, 2009-08-27 [InstanceEdit:445739] Jassal, Bijay, 2009-11-05 [InstanceEdit:446288] Jassal, Bijay, 2009-11-12 [InstanceEdit:5624215] Jassal, Bijay, 2014-09-22 [InstanceEdit:8959771] Jassal, Bijay, 2017-01-31 [InstanceEdit:9645221] Jassal, Bijay, 2019-05-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9958698] Stephan, Ralf, 2025-06-24 [InstanceEdit:9963193] Stephan, Ralf, 2025-08-13
name	SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol MCTs mediate proton-coupled transport of monocarboxylates and ketone bodies
negativePrecedingEvent	[NegativePrecedingEvent:9963192] Futile Cycle: BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region
output	[SimpleEntity:70106] H+ [cytosol] [DefinedSet:433686] MCT substrates [cytosol]
precedingEvent	[Reaction:561253] SLC22A12 exchanges extracellular urate for cytosolic LACT [Homo sapiens] [Reaction:373867] BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol [Homo sapiens] [Reaction:9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol [Homo sapiens] [Reaction:433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol [Homo sapiens] [Reaction:8876312] SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol [Homo sapiens] [Reaction:429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol [Homo sapiens]
releaseDate	2009-12-15
reviewed	[InstanceEdit:446289] He, Lei, 2009-11-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104237] R-HSA-433698.5
summation	[Summation:433700] Four members of the SLC16A gene family encode classical mono...
(hasEvent)	[Pathway:433692] Proton-coupled monocarboxylate transport [Homo sapiens] [Pathway:8941514] Orphan 6 events [Homo sapiens]
(precedingEvent)	[Reaction:561253] SLC22A12 exchanges extracellular urate for cytosolic LACT [Homo sapiens] [NegativePrecedingEvent:9963195] Futile Cycle: SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol
(updatedInstance)	[_UpdateTracker:9777741] Update Tracker - [Reaction:433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - v69:[removeLiteratureReference] [_UpdateTracker:9781582] Update Tracker - [Reaction:433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - v60:[addLiteratureReference, modifyText] [_UpdateTracker:9784237] Update Tracker - [Reaction:433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - v54:[modifyText] [_UpdateTracker:9785766] Update Tracker - [Reaction:433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - v51:[modifyText]
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