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Details on Person NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3

Class:Id	BlackBoxEvent:433672
_displayName	NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3
_doRelease	TRUE
_timestamp	2018-02-16 03:56:10
authored	[InstanceEdit:427381] May, B, 2009-06-19
catalystActivity	[CatalystActivity:573370] histone deacetylase activity of NoRC:pRNA:HDAC:DNMT [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:433671] May, B, 2009-08-24
edited	[InstanceEdit:427381] May, B, 2009-06-19
inferredFrom	[BlackBoxEvent:573376] NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene [Mus musculus]
input	[SimpleEntity:77087] AdoMet [nucleoplasm] [Complex:5226874] Chromatin (H4K5ac, H4K8ac, H4K16ac) [nucleoplasm] [Homo sapiens]
modified	[InstanceEdit:427428] May, B, 2009-06-21 [InstanceEdit:427488] May, B, 2009-06-23 [InstanceEdit:433675] May, B, 2009-08-24 [InstanceEdit:433677] May, B, 2009-08-24 [InstanceEdit:573322] May, B, 2010-04-10 [InstanceEdit:5084121] May, B, 2013-11-08 [InstanceEdit:5226878] May, B, 2014-01-08 [InstanceEdit:5227492] May, B, 2014-01-09 [InstanceEdit:5250950] May, B, 2014-01-31 [InstanceEdit:5332992] May, B, 2014-02-18 [InstanceEdit:9036997] May, Bruce, 2018-02-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 Deacetylation of Histone H4 and Dimethylation of Lysine-9 of Histone H3 in Promoter of rRNA Gene
output	[SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:427486] CH3COO- [nucleoplasm] [Complex:3211683] Chromatin (H3K9me2) [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:427409] Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA [Homo sapiens] [Reaction:74987] TTF1 binds to the Sal Box [Homo sapiens] [BlackBoxEvent:427394] Cleavage of intergenic spacer RNA to yield fragments of 150-300 nucleotides [Homo sapiens]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5332991] Shiao, YH, 2014-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644820] R-HSA-433672.3
summation	[Summation:433673] As inferred from mouse cell models, histones in silenced rRN...
(hasEvent)	[Pathway:427413] NoRC negatively regulates rRNA expression [Homo sapiens]
(precedingEvent)	[Reaction:5227490] NoRC:HDAC:DNMT methylates cytosine of the rRNA genes [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779700] Update Tracker - [BlackBoxEvent:433672] NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 - v64:[removeCatalystActivity]
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No pathways have been reviewed or authored by NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 (433672)