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Details on Person ceramide + H2O => stearate + sphingosine [endoplasmic reticulum]

Class:Id	Reaction:433608
_displayName	ceramide + H2O => stearate + sphingosine [endoplasmic reticulum]
_doRelease	TRUE
_timestamp	2016-11-10 00:56:52
catalystActivity	[CatalystActivity:433548] N-acylsphingosine amidohydrolase activity of ACER1 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:433625] D'Eustachio, P, 2009-08-22
inferredFrom	[Reaction:428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum) [Homo sapiens]
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:428256] CERA [endoplasmic reticulum membrane]
modified	[InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1168648] D'Eustachio, P, 2011-01-03 [InstanceEdit:1667320] D'Eustachio, P, 2011-10-14 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ceramide + H2O => stearate + sphingosine [endoplasmic reticulum]
output	[SimpleEntity:428193] SPG [endoplasmic reticulum membrane] [SimpleEntity:428198] STEA [early endosome]
precedingEvent	[Reaction:433599] dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O [Gallus gallus] [Reaction:433592] sphinganine + stearyl-CoA => dihydroceramide + CoASH [Gallus gallus]
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:2016244] R-GGA-433608.3
summation	[Summation:433571] ACER1 (alkaline ceramidase 1), associated with the endoplasm...
(hasEvent)	[Pathway:433584] Sphingolipid metabolism [Gallus gallus]
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No pathways have been reviewed or authored by ceramide + H2O => stearate + sphingosine [endoplasmic reticulum] (433608)