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Details on Person Translocation and activation of PKC alpha in response to WNT signaling

Class:Id	Reaction:4332390
_displayName	Translocation and activation of PKC alpha in response to WNT signaling
_doRelease	TRUE
_timestamp	2024-03-07 02:49:05
authored	[InstanceEdit:4420051] Rothfels, K, 2013-08-29
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:4332391] Rothfels, K, 2013-08-16
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
inferredFrom	[Reaction:4332392] translocation of Xenopus prkca to plasma membrane [Xenopus laevis]
input	[SimpleEntity:74016] Ca2+ [cytosol] [SimpleEntity:74016] Ca2+ [cytosol] [SimpleEntity:74016] Ca2+ [cytosol] [SimpleEntity:114519] DAG [plasma membrane] [SimpleEntity:33625] PS [plasma membrane] [EntityWithAccessionedSequence:4332337] p-T497,T638,S657-PRKCA [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:4332322] Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner [LiteratureReference:3247705] The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape [LiteratureReference:3965321] The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition [LiteratureReference:4518576] Wnt5A activates the calpain-mediated cleavage of filamin A [LiteratureReference:3965336] Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma
modified	[InstanceEdit:4518591] Rothfels, K, 2013-09-03 [InstanceEdit:5097367] Rothfels, K, 2013-11-11 [InstanceEdit:5144302] Rothfels, K, 2013-11-15 [InstanceEdit:6782938] Rothfels, Karen, 2015-06-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9864375] Orlic-Milacic, Marija, 2024-03-07
name	Translocation and activation of PKC alpha in response to WNT signaling
output	[Complex:4332385] activated PKC alpha [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:398193] PLC beta-mediated PIP2 hydrolysis [Homo sapiens] [Reaction:398040] Gbeta:gamma activation of PLC beta [Homo sapiens] [Reaction:4420052] Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT [Homo sapiens] [Reaction:169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel [Homo sapiens]
releaseDate	2013-12-04
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644467] R-HSA-4332390.4
summation	[Summation:4518587] Ectopic expression of Xwnt5a or Rfz2 in Xenopus embryos resu...
(hasEvent)	[Pathway:4086398] Ca2+ pathway [Homo sapiens]
(precedingEvent)	[Reaction:2730872] Activation of Calcineurin [Homo sapiens]
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