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Details on Person CBL neddylates TGFBR2

Class:IdReaction:4332236
_displayNameCBL neddylates TGFBR2
_doReleaseTRUE
_timestamp2022-02-10 17:22:03
authored[InstanceEdit:4332289] Orlic-Milacic, M, 2013-08-16
catalystActivity[CatalystActivity:4332230] ubiquitin-protein transferase activity of TGFBR2:CBL [plasma membrane]
catalystActivityReference[CatalystActivityReference:9643988] ubiquitin-protein transferase activity of TGFBR2:CBL [plasma membrane] c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-? type II receptor
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:4332218] Orlic-Milacic, M, 2013-08-16
edited[InstanceEdit:4341133] May, B, 2013-08-18
input[Complex:4332229] TGFBR2:CBL [plasma membrane] [Homo sapiens]
[Complex:4419896] NEDD8-AcM-UBE2M [cytosol] [Homo sapiens]
[Complex:4419896] NEDD8-AcM-UBE2M [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:4332219] c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-? type II receptor
modified[InstanceEdit:4332242] Orlic-Milacic, M, 2013-08-16
[InstanceEdit:4332286] Orlic-Milacic, M, 2013-08-16
[InstanceEdit:4332287] Orlic-Milacic, M, 2013-08-16
[InstanceEdit:4419861] Orlic-Milacic, M, 2013-08-28
[InstanceEdit:4419908] Orlic-Milacic, M, 2013-08-28
[InstanceEdit:4419909] Orlic-Milacic, M, 2013-08-28
[InstanceEdit:4419923] Orlic-Milacic, M, 2013-08-28
[InstanceEdit:8951738] Rothfels, Karen, 2016-12-09
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9764246] May, Bruce, 2022-02-10
[InstanceEdit:9764251] May, Bruce, 2022-02-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameCBL neddylates TGFBR2
output[EntityWithAccessionedSequence:112199] CBL [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:8951627] AcM-UBE2M [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:8951627] AcM-UBE2M [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:4332222] NEDD8-K556,K567-TGFBR2 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2013-09-18
reviewed[InstanceEdit:4419860] Chen, Ye-Guang, 2013-08-28
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:4545255] R-HSA-4332236.5
summation[Summation:4332284] CBL neddylates TGFBR2 on lysine residues K556 and K567. The ...
(hasEvent)[Pathway:2173789] TGF-beta receptor signaling activates SMADs [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775228] Update Tracker - [Reaction:4332236] CBL neddylates TGFBR2 - v80:[add_removeOutput]
[_UpdateTracker:9781536] Update Tracker - [Reaction:4332236] CBL neddylates TGFBR2 - v60:[add_removeOutput]
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No pathways have been reviewed or authored by CBL neddylates TGFBR2 (4332236)
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