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Details on Person Trimethylation of Histone H3 at Lysine-9 and Deacetylation of Histone H4 by Heterochromatic Replication Complex

Class:Id	BlackBoxEvent:433155
_displayName	Trimethylation of Histone H3 at Lysine-9 and Deacetylation of Histone H4 by Heterochromatic Replication Complex
_timestamp	2016-07-15 23:49:56
authored	[InstanceEdit:212086] May, B, Gopinathrao, G, 2008-02-08 19:50:06
catalystActivity	[CatalystActivity:212149] histone deacetylase activity of Heterochromatin Replication Complex [nucleoplasm] [CatalystActivity:212179] histone H3K9 methyltransferase activity of Heterochromatin Replication Complex [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:433154] May, B, 2009-08-21
edited	[InstanceEdit:565730] May, B, 2010-04-06
input	[Complex:433152] Nucleosome with Replicative H3K9me1, H4K5ac, H4K12ac [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm]
literatureReference	[LiteratureReference:427759] Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis [LiteratureReference:427757] Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains [LiteratureReference:427733] The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin [LiteratureReference:996696] PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state [LiteratureReference:996700] Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases [LiteratureReference:212148] Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification [LiteratureReference:1013900] Histones in transit: cytosolic histone complexes and diacetylation of H4 during nucleosome assembly in human cells [LiteratureReference:1013908] Structure and function of the histone chaperone CIA/ASF1 complexed with histones H3 and H4 [LiteratureReference:1013893] Modifications of H3 and H4 during chromatin replication, nucleosome assembly, and histone exchange [LiteratureReference:212022] Purification and characterization of CAF-I, a human cell factor required for chromatin assembly during DNA replication in vitro [LiteratureReference:1013894] Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly
modified	[InstanceEdit:433168] May, B, 2009-08-21 [InstanceEdit:433169] May, B, 2009-08-21 [InstanceEdit:433178] May, B, 2009-08-21 [InstanceEdit:565730] May, B, 2010-04-06 [InstanceEdit:573322] May, B, 2010-04-10 [InstanceEdit:996693] May, B, 2010-11-08 [InstanceEdit:1013907] May, B, 2010-11-12 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	Trimethylation of Histone H3 at Lysine-9 and Deacetylation of Histone H4 by Heterochromatic Replication Complex
output	[Complex:433153] Nucleosome with Replicative H3K9me3 [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:212067] Monomethylation of Histone H3 at Lysine-9 by Heterochromatin Replication Complex [Homo sapiens] [BlackBoxEvent:417138] Formation of Heterochromatin Replication Complex [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8907704] R-HSA-433155.1
summation	[Summation:433176] Newly synthesized Histone H4 in humans has acetylated lysine...
(hasEvent)	[Pathway:212161] Maintenance of Pericentric Heterochromatin During Replication [Homo sapiens]
(precedingEvent)	[Reaction:212054] Methylation of Cytosine Residues in CpG Motifs by Heterochromatin Replication Complex [Homo sapiens]
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No pathways have been reviewed or authored by Trimethylation of Histone H3 at Lysine-9 and Deacetylation of Histone H4 by Heterochromatic Replication Complex (433155)