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Details on Person PER is phosphorylated by DCO

Class:IdReaction:432559
_displayNamePER is phosphorylated by DCO
_doReleaseTRUE
_timestamp2018-03-09 00:15:49
authored[InstanceEdit:432420] Williams, MG, 2009-08-13
catalystActivity[CatalystActivity:208884] protein serine/threonine kinase activity of AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:432644] Williams, MG, 2009-08-14
edited[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure[Figure:901091] /figures/DrosCircClockD05.jpg
input[Complex:432347] PER:DCO [cytosol] [Drosophila melanogaster]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:432526] Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime
[LiteratureReference:432446] The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock
[LiteratureReference:538819] The F-box protein slimb controls the levels of clock proteins period and timeless
modified[InstanceEdit:538918] Williams, MG, 2010-03-08
[InstanceEdit:882016] Williams, MG, 2010-06-28
[InstanceEdit:901092] Williams, MG, 2010-07-02
[InstanceEdit:909539] Williams, MG, 2010-07-07
[InstanceEdit:912304] Williams, MG, 2010-07-08
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9024541] Matthews, Lisa, 2017-10-05
[InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePER is phosphorylated by DCO
output[Complex:881987] Phospho (multi-site 1) PER:DCO [cytosol] [Drosophila melanogaster]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2017-09-12
reviewed[InstanceEdit:909536] Edery, I, 2010-07-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:56210] Drosophila melanogaster
stableIdentifier[StableIdentifier:8914884] R-DME-432559.4
summation[Summation:432451] Period (PER) is phosphorylated on between 15-20 individual s...
(hasEvent)[Pathway:432553] Phosphorylation of PER and TIM [Drosophila melanogaster]
(precedingEvent)[BlackBoxEvent:432411] SLMB binds phosphorylated cytosolic PER, facilitating its ubiquitination [Drosophila melanogaster]
[Reaction:432556] Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO [Drosophila melanogaster]
[Reaction:432647] Phosphorylated PER binds to TIM [Drosophila melanogaster]
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