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Details on Person TIM is phosphorylated by CK2

Class:IdReaction:432535
_displayNameTIM is phosphorylated by CK2
_doReleaseTRUE
_timestamp2018-03-09 00:19:00
authored[InstanceEdit:432420] Williams, MG, 2009-08-13
catalystActivity[CatalystActivity:208934] protein serine/threonine kinase activity of RAS85D:GTP:SRC42A:Phospho CNK:14-3-3epsilon dimer:Phospho PHL:Phospho KSR:14-3-3epsilon dimer:AVE:DSOR1:CK2:PAR-1:PP2A [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:432644] Williams, MG, 2009-08-14
edited[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure[Figure:881943] /figures/DrosCircClockC09.jpg
input[Complex:881912] TIM:Phospho (multi-site 2) PER:DCO [cytosol] [Drosophila melanogaster]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:432643] TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo
modified[InstanceEdit:538918] Williams, MG, 2010-03-08
[InstanceEdit:882016] Williams, MG, 2010-06-28
[InstanceEdit:909539] Williams, MG, 2010-07-07
[InstanceEdit:912304] Williams, MG, 2010-07-08
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9024541] Matthews, Lisa, 2017-10-05
[InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTIM is phosphorylated by CK2
output[Complex:881944] Phospho TIM:Phospho (multi-site 2) PER:DCO [cytosol] [Drosophila melanogaster]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2017-09-12
reviewed[InstanceEdit:909536] Edery, I, 2010-07-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:56210] Drosophila melanogaster
stableIdentifier[StableIdentifier:8911261] R-DME-432535.4
summation[Summation:432573] Timeless (TIM) is phosphorylated on unknown serine/threonine...
(hasEvent)[Pathway:432553] Phosphorylation of PER and TIM [Drosophila melanogaster]
(precedingEvent)[Reaction:432464] Phosphorylated TIM:PER heterodimer dissociate [Drosophila melanogaster]
[Reaction:538824] PP1 binds to phosphorylated TIM in complex with PER [Drosophila melanogaster]
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