Query author contributions in Reactome
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Details on Person During the day, with levels of its stabilising partner Timel...
| Class:Id | Summation:432494 |
|---|---|
| _displayName | During the day, with levels of its stabilising partner Timel... |
| _timestamp | 2020-02-26 16:15:28 |
| created | [InstanceEdit:432644] Williams, MG, 2009-08-14 |
| modified | [InstanceEdit:538918] Williams, MG, 2010-03-08 [InstanceEdit:882015] Williams, MG, 2010-06-28 [InstanceEdit:9677062] D'Eustachio, Peter, 2020-02-26 |
| text | During the day, with levels of its stabilising partner Timeless (TIM) drastically reduced by light, hyperphosphorylated Period (PER) becomes a target for the F-box containing protein, supernumerary limbs (SLMB). Ser47 phosphorylation of Period (PER) appears to be the trigger for SLMB to bind phosphorylated PER, facilitating its ubiquitination and marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for PER degradation are the same. |
| (summation) | [BlackBoxEvent:432483] SLMB binds phosphorylated nuclear PER, facilitating its ubiquitination [Drosophila melanogaster] |
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No pathways have been reviewed or authored by During the day, with levels of its stabilising partner Timel... (432494)
