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Details on Person SLMB binds phosphorylated nuclear PER, facilitating its ubiquitination

Class:Id	BlackBoxEvent:432483
_displayName	SLMB binds phosphorylated nuclear PER, facilitating its ubiquitination
_doRelease	TRUE
_timestamp	2020-02-27 14:22:44
authored	[InstanceEdit:432420] Williams, MG, 2009-08-13
catalystActivity	[CatalystActivity:9677105] ubiquitin-like ligase-substrate adaptor activity of SLMB [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9677110] protein binding, bridging involved in substrate recognition for ubiquitination activity of SLMB [nucleoplasm] Roles of F-box proteins in cancer
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:432644] Williams, MG, 2009-08-14
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure	[Figure:881993] /figures/DrosCircClockC20.jpg
input	[Complex:881927] Phospho CLK:CYC:Phospho (multi-site 2) PER:DCO [nucleoplasm] [Drosophila melanogaster] [EntityWithAccessionedSequence:432469] SLMB [nucleoplasm] [Drosophila melanogaster] [DefinedSet:216110] UBI-P63E [nucleoplasm] [Drosophila melanogaster]
literatureReference	[LiteratureReference:432446] The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock [LiteratureReference:432526] Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime [LiteratureReference:538819] The F-box protein slimb controls the levels of clock proteins period and timeless
modified	[InstanceEdit:538918] Williams, MG, 2010-03-08 [InstanceEdit:882016] Williams, MG, 2010-06-28 [InstanceEdit:909539] Williams, MG, 2010-07-07 [InstanceEdit:912304] Williams, MG, 2010-07-08 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9024541] Matthews, Lisa, 2017-10-05 [InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09 [InstanceEdit:9677062] D'Eustachio, Peter, 2020-02-26 [InstanceEdit:9677109] D'Eustachio, Peter, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SLMB binds phosphorylated nuclear PER, facilitating its ubiquitination
output	[Complex:882001] Phospho CLK:CYC:SLMB:UBI-P63E:Phospho (multi-site 2) PER:DCO [nucleoplasm] [Drosophila melanogaster]
precedingEvent	[Reaction:432371] CRY is activated by light and binds to phosphorylated nuclear TIM [Drosophila melanogaster] [Reaction:432381] PDP1 replaces VRI as binder to Clk and cry genes [Drosophila melanogaster] [Reaction:538891] CLK:CYC heterodimer dissociates from per, tim, vri, and Pdp1 genes [Drosophila melanogaster] [BlackBoxEvent:432424] JET binds phosphorylated nuclear TIM, facilitating its ubiquitination [Drosophila melanogaster] [BlackBoxEvent:432455] Nuclear PER is degraded by the 26S proteasome [Drosophila melanogaster] [BlackBoxEvent:432483] SLMB binds phosphorylated nuclear PER, facilitating its ubiquitination [Drosophila melanogaster]
releaseDate	2017-09-12
reviewed	[InstanceEdit:909536] Edery, I, 2010-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9677063] D'Eustachio, Peter, 2020-02-26
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8885164] R-DME-432483.5
summation	[Summation:432494] During the day, with levels of its stabilising partner Timel...
(hasEvent)	[Pathway:432524] Degradation of PER [Drosophila melanogaster]
(precedingEvent)	[BlackBoxEvent:432455] Nuclear PER is degraded by the 26S proteasome [Drosophila melanogaster]
(updatedInstance)	[_UpdateTracker:9777145] Update Tracker - [BlackBoxEvent:432483] SLMB binds phosphorylated nuclear PER, facilitating its ubiquitination - v72:[add_removeCatalystActivity, modifyText]
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