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Details on Person JET binds cytosolic TIM, facilitating its ubiquitination

Class:IdBlackBoxEvent:432401
_displayNameJET binds cytosolic TIM, facilitating its ubiquitination
_doReleaseTRUE
_timestamp2020-02-27 14:22:42
authored[InstanceEdit:432420] Williams, MG, 2009-08-13
catalystActivity[CatalystActivity:9677108] ubiquitin-like ligase-substrate adaptor activity of JET [cytosol]
catalystActivityReference[CatalystActivityReference:9677103] protein binding, bridging involved in substrate recognition for ubiquitination activity of JET [cytosol] Roles of F-box proteins in cancer
compartment[Compartment:70101] cytosol
created[InstanceEdit:432644] Williams, MG, 2009-08-14
edited[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure[Figure:881940] /figures/DrosCircClockC23.jpg
input[Complex:881918] TIM:CRY [cytosol] [Drosophila melanogaster]
[EntityWithAccessionedSequence:432571] JET [cytosol] [Drosophila melanogaster]
[DefinedSet:206204] UBI-P63E [cytosol] [Drosophila melanogaster]
literatureReference[LiteratureReference:432588] JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS
[LiteratureReference:432404] Light-dependent interactions between the Drosophila circadian clock factors cryptochrome, jetlag, and timeless
modified[InstanceEdit:538918] Williams, MG, 2010-03-08
[InstanceEdit:882016] Williams, MG, 2010-06-28
[InstanceEdit:909539] Williams, MG, 2010-07-07
[InstanceEdit:912304] Williams, MG, 2010-07-08
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9024533] Matthews, Lisa, 2017-10-05
[InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09
[InstanceEdit:9677062] D'Eustachio, Peter, 2020-02-26
[InstanceEdit:9677109] D'Eustachio, Peter, 2020-02-27
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameJET binds cytosolic TIM, facilitating its ubiquitination
output[Complex:881984] UBI-P63E:TIM:JET [cytosol] [Drosophila melanogaster]
[EntityWithAccessionedSequence:432574] CRY [cytosol] [Drosophila melanogaster]
precedingEvent
releaseDate2017-09-12
reviewed[InstanceEdit:909536] Edery, I, 2010-07-06
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:9677063] D'Eustachio, Peter, 2020-02-26
species[Species:56210] Drosophila melanogaster
stableIdentifier[StableIdentifier:8894755] R-DME-432401.5
summation[Summation:432345] There is competition for binding to the E3 ligase protein Je...
(hasEvent)[Pathway:432395] Degradation of TIM [Drosophila melanogaster]
(precedingEvent)[Reaction:432426] CRY is activated by light and binds to cytosolic TIM [Drosophila melanogaster]
[BlackBoxEvent:432507] Cytosolic TIM is degraded by the 26S proteasome [Drosophila melanogaster]
[BlackBoxEvent:432593] Cytosolic JET binds to CRY, facilitating its ubiquitination [Drosophila melanogaster]
(updatedInstance)[_UpdateTracker:9777240] Update Tracker - [BlackBoxEvent:432401] JET binds cytosolic TIM, facilitating its ubiquitination - v72:[add_removeCatalystActivity, modifyText]
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