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Details on Person SLP-76 inducibly-associates with ADAP (also known as FYN-bin...

Class:Id	Summation:430123
_displayName	SLP-76 inducibly-associates with ADAP (also known as FYN-bin...
_timestamp	2009-11-02 18:09:19
created	[InstanceEdit:430144] Jupe, S, 2009-07-31
literatureReference	[LiteratureReference:430136] The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton [LiteratureReference:430133] Coupling of the TCR to integrin activation by Slap-130/Fyb [LiteratureReference:430145] Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton [LiteratureReference:445661] ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists
modified	[InstanceEdit:445664] Jupe, S, 2009-11-02
text	SLP-76 inducibly-associates with ADAP (also known as FYN-binding protein or SLAP-130) a hematopoietic-specific adapter protein. ADAP has been implicated in T cell migration and rearrangement of the actin cytoskeleton. In platelets, adhesion to fibrinogen stimulates the association of SLP-76 with ADAP and VASP (Obergfell et al. 2001). ADAP knockout mice exhibit mild thrombocytopenia (Kasirer-Friede et al. 2007).
(summation)	[Reaction:430135] p-SLP-76 binds ADAP [Homo sapiens]
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No pathways have been reviewed or authored by SLP-76 inducibly-associates with ADAP (also known as FYN-bin... (430123)