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Details on Person PARN deadenylates mRNA
Class:Id Reaction:429992 _displayName PARN deadenylates mRNA _doRelease TRUE _timestamp 2014-02-05 02:41:36 authored [InstanceEdit:430015] May, B, 2009-07-22 catalystActivity [CatalystActivity:430048] poly(A)-specific ribonuclease activity of PARN homodimer [cytosol] compartment [Compartment:70101] cytosol created [InstanceEdit:429836] May, B, 2009-07-23 edited [InstanceEdit:430015] May, B, 2009-07-22 input [Complex:429989] Partially Deadenylated mRNA Complex [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol] literatureReference [LiteratureReference:433055] Poly(A) tail shortening by a mammalian poly(A)-specific 3'-exoribonuclease [LiteratureReference:430018] Properties of a HeLa cell 3' exonuclease specific for degrading poly(A) tails of mammalian mRNA [LiteratureReference:429931] Interaction between a poly(A)-specific ribonuclease and the 5' cap influences mRNA deadenylation rates in vitro [LiteratureReference:429957] The highways and byways of mRNA decay [LiteratureReference:429946] Messenger RNA decay in mammalian cells: the exonuclease perspective [LiteratureReference:429954] The many pathways of RNA degradation [LiteratureReference:430040] From birth to death: the complex lives of eukaryotic mRNAs [LiteratureReference:429833] The enzymes and control of eukaryotic mRNA turnover [LiteratureReference:430007] The cap-to-tail guide to mRNA turnover [LiteratureReference:442442] Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation modified [InstanceEdit:432737] May, B, 2009-08-15 [InstanceEdit:433053] May, B, 2009-08-20 [InstanceEdit:442446] May, B, 2009-09-27 [InstanceEdit:446678] May, B, 2009-11-16 [InstanceEdit:5251727] May, B, 2014-02-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name PARN deadenylates mRNA output [SimpleEntity:76577] AMP [cytosol] [OtherEntity:429974] mature mRNA (eukaryotic, capped and deadenylated) [cytosol] [EntityWithAccessionedSequence:156803] PABPC1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:429861] PAIP1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:72589] EIF4B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:72578] EIF4E [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:72584] EIF4G1 [cytosol] [Homo sapiens] [DefinedSet:429842] eIF4A [cytosol] [Homo sapiens] precedingEvent
releaseDate 2009-12-15 reviewed [InstanceEdit:442431] Wilusz, J, 2009-09-17 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:1104486] R-HSA-429992.2 summation [Summation:429837] The PARN exoribonuclease hydrolyzes adenosine residues at th... (hasEvent) [Pathway:429947] Deadenylation of mRNA [Homo sapiens] (precedingEvent) [Reaction:429978] Lsm1-7 Complex binds deadenylated mRNA [Homo sapiens] [Reaction:430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion [Homo sapiens]
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