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Details on Person CCR4-NOT complex deadenylates mRNA

Class:Id	Reaction:429955
_displayName	CCR4-NOT complex deadenylates mRNA
_doRelease	TRUE
_timestamp	2014-02-05 02:39:52
authored	[InstanceEdit:430015] May, B, 2009-07-22
catalystActivity	[CatalystActivity:429904] poly(A)-specific ribonuclease activity of CCR4-NOT Complex [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:429836] May, B, 2009-07-23
edited	[InstanceEdit:430015] May, B, 2009-07-22
input	[Complex:429989] Partially Deadenylated mRNA Complex [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:433062] CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase [LiteratureReference:429874] Human Ccr4-Not complexes contain variable deadenylase subunits [LiteratureReference:433061] Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits [LiteratureReference:429957] The highways and byways of mRNA decay [LiteratureReference:429884] Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover [LiteratureReference:429929] Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells [LiteratureReference:429946] Messenger RNA decay in mammalian cells: the exonuclease perspective [LiteratureReference:429954] The many pathways of RNA degradation [LiteratureReference:430040] From birth to death: the complex lives of eukaryotic mRNAs [LiteratureReference:429833] The enzymes and control of eukaryotic mRNA turnover [LiteratureReference:430007] The cap-to-tail guide to mRNA turnover
modified	[InstanceEdit:432738] May, B, 2009-08-15 [InstanceEdit:433063] May, B, 2009-08-20 [InstanceEdit:442447] May, B, 2009-09-27 [InstanceEdit:446678] May, B, 2009-11-16 [InstanceEdit:5251727] May, B, 2014-02-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CCR4-NOT complex deadenylates mRNA
output	[SimpleEntity:76577] AMP [cytosol] [OtherEntity:429974] mature mRNA (eukaryotic, capped and deadenylated) [cytosol] [EntityWithAccessionedSequence:156803] PABPC1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:429861] PAIP1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:72589] EIF4B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:72578] EIF4E [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:72584] EIF4G1 [cytosol] [Homo sapiens] [DefinedSet:429842] eIF4A [cytosol] [Homo sapiens]
precedingEvent	[Reaction:430021] PAN2-PAN3 complex partially deadenylates mRNA [Homo sapiens] [Reaction:75098] mRNP complex dissociates from cytosolic face of NPC [Homo sapiens]
releaseDate	2009-12-15
reviewed	[InstanceEdit:442431] Wilusz, J, 2009-09-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104763] R-HSA-429955.2
summation	[Summation:429933] The CCR4-NOT complex hydrolyzes adenosine residues at the 3'...
(hasEvent)	[Pathway:429947] Deadenylation of mRNA [Homo sapiens]
(precedingEvent)	[Reaction:429978] Lsm1-7 Complex binds deadenylated mRNA [Homo sapiens] [Reaction:430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion [Homo sapiens]
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No pathways have been reviewed or authored by CCR4-NOT complex deadenylates mRNA (429955)