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Details on Person 5' to 3' exoribonuclease hydrolyzes decapped mRNA

Class:Id	Reaction:429845
_displayName	5' to 3' exoribonuclease hydrolyzes decapped mRNA
_doRelease	TRUE
_timestamp	2014-02-05 02:39:20
authored	[InstanceEdit:430015] May, B, 2009-07-22
catalystActivity	[CatalystActivity:429949] 5'-3' RNA exonuclease activity of XRN1 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:429836] May, B, 2009-07-23
edited	[InstanceEdit:430015] May, B, 2009-07-22
inferredFrom	[Reaction:429913] 5' to 3' Exoribonuclease Digestion of Decapped mRNA (yeast) [Saccharomyces cerevisiae]
input	[Complex:429996] Decapped mRNA:LSM1-7 Complex [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:429880] The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci [LiteratureReference:429939] ARE-mRNA degradation requires the 5'-3' decay pathway [LiteratureReference:429957] The highways and byways of mRNA decay [LiteratureReference:429946] Messenger RNA decay in mammalian cells: the exonuclease perspective [LiteratureReference:429954] The many pathways of RNA degradation [LiteratureReference:430040] From birth to death: the complex lives of eukaryotic mRNAs [LiteratureReference:429833] The enzymes and control of eukaryotic mRNA turnover [LiteratureReference:430007] The cap-to-tail guide to mRNA turnover
modified	[InstanceEdit:432735] May, B, 2009-08-15 [InstanceEdit:433048] May, B, 2009-08-20 [InstanceEdit:442437] May, B, 2009-09-27 [InstanceEdit:446678] May, B, 2009-11-16 [InstanceEdit:5251727] May, B, 2014-02-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	5' to 3' exoribonuclease hydrolyzes decapped mRNA
output	[SimpleEntity:76577] AMP [cytosol] [SimpleEntity:113578] GMP [cytosol] [SimpleEntity:109395] CMP [cytosol] [SimpleEntity:109402] UMP [cytosol] [Complex:430001] Lsm1-7 Complex [cytosol] [Homo sapiens]
precedingEvent	[Reaction:429860] DCP1-DCP2 complex decaps mRNA [Homo sapiens] [Reaction:429978] Lsm1-7 Complex binds deadenylated mRNA [Homo sapiens]
releaseDate	2009-12-15
reviewed	[InstanceEdit:442431] Wilusz, J, 2009-09-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105360] R-HSA-429845.2
summation	[Summation:429854] The XRN1 exoribonuclease hydrolyzes decapped mRNA from 5' to...
(hasEvent)	[Pathway:430039] mRNA decay by 5' to 3' exoribonuclease [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9764209] Futile Cycle: 5' to 3' exoribonuclease hydrolyzes decapped mRNA
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