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Details on Person The PARN exoribonuclease hydrolyzes adenosine residues at th...
| Class:Id | Summation:429837 |
|---|---|
| _displayName | The PARN exoribonuclease hydrolyzes adenosine residues at th... |
| _timestamp | 2009-09-27 04:30:00 |
| created | [InstanceEdit:429836] May, B, 2009-07-23 |
| modified | [InstanceEdit:430058] May, B, 2009-07-24 [InstanceEdit:442453] May, B, 2009-09-27 |
| text | The PARN exoribonuclease hydrolyzes adenosine residues at the 3' ends of polyadenylated mRNA, shortening the poly(A) tail from about 80 adenosine residues to about 10-15 residues and yielding adenosine 5'-monophosphate. PARN interacts simultaneously with the poly(A) tail and with the 7-methylguanosine cap of the mRNA, therefore it is believed that PARN displaces the eIF4F cap-binding complex. The trigger for deadenylation by PARN is unknown. PARN is also part of a complex that regulates poly(A) tail length and hence translation in developing oocytes. |
| (summation) | [Reaction:429992] PARN deadenylates mRNA [Homo sapiens] |
| [Change default viewing format] | |
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